Fate plasticity of adult hippocampal progenitors: biological relevance and therapeutic use.

Trends in Pharmacological Sciences
Sebastian Jessberger, Fred H Gage

Abstract

Adult hippocampal stem/progenitor cells (AHPs) continuously give rise to new neurons throughout life, which might be an important determinant of hippocampus-dependent function. Strikingly, the fate potential of AHPs is not restricted to the neuronal lineage because AHPs can be genetically induced to generate oligodendrocytes within their in vivo niche by AHP-specific ectopic expression of the basic-helix-loop-helix (bHLH) transcription factor achaete-scute complex-like 1 (ASCL1). Fate plasticity of AHPs is controlled by cell-autonomous and also niche-dependent mechanisms. Here, we discuss the biological importance and potential therapeutic applications of retained fate plasticity of AHPs in the adult mammalian brain in addition to the future scientific inquiries indicated by this finding.

References

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Mar 5, 2002·Nature·Henriette van PraagFred H Gage
May 3, 2002·Nature·Hongjun SongFred H Gage
Jun 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Helena FrielingsdorfPaul Mohapel
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Nov 22, 2007·Science·Junying YuJames A Thomson
Feb 26, 2008·Cell·Chunmei ZhaoFred H Gage
May 2, 2008·Development·Christophe GalichetCarlos M Parras
May 16, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tara L WalkerPerry F Bartlett
Jul 1, 2008·Nature Neuroscience·Sebastian JessbergerFred H Gage
Aug 7, 2008·Cell Stem Cell·Steven A Goldman, Sridaran Natesan

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Citations

Jan 22, 2014·Glia·Robin J M Franklin, Vittorio Gallo
Mar 17, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jun Ming WangRoberta Diaz Brinton

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