Fatigue after a first attack of suspected multiple sclerosis

Multiple Sclerosis : Clinical and Laboratory Research
Roos M van der Vuurst de VriesR Q Hintzen

Abstract

Fatigue is reported by more than 75% of multiple sclerosis (MS) patients. In an earlier study, we showed that fatigue is not only a common symptom in patients at time of clinically isolated syndrome (CIS; fatigued 46%) but also predicts subsequent diagnosis of clinically definite multiple sclerosis (CDMS). The course of fatigue after CIS is unknown. We aimed to explore the long-term course of fatigue after CIS. In this study, 235 CIS patients, aged 18-50 years, were prospectively followed. Patients filled in the Krupp's Fatigue Severity Scale (FSS) and the Hospital Anxiety and Depression Scale (HADS) at baseline and annually. After reaching CDMS diagnosis, Expanded Disability Status Scale (EDSS) was obtained annually. Mixed-effects models were used to analyse longitudinal FSS measurements. Fatigue at baseline was an independent predictor for CDMS diagnosis (hazard ratio (HR): 2.6, 95% confidence interval (CI): 1.6-4.4). The evolution of FSS was the same in CIS patients who remained monophasic and patients who were diagnosed with CDMS during follow-up. However, FSS increased by 0.86 units after reaching CDMS diagnosis ( p = 0.01). After this increase, the FSS course remained unaltered ( p = 0.44). Fatigue, which is often present...Continue Reading

References

Mar 1, 1983·Annals of Neurology·C M PoserW W Tourtellotte
Jun 1, 1983·Acta Psychiatrica Scandinavica·A S Zigmond, R P Snaith
Apr 25, 2000·Multiple Sclerosis : Clinical and Laboratory Research·D C KroenckeD R Denney
Jun 20, 2003·Multiple Sclerosis : Clinical and Laboratory Research·Rohit Bakshi
Dec 20, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·C HeesenS M Gold
Feb 8, 2006·Multiple Sclerosis : Clinical and Laboratory Research·S L MindenD C Hoaglin
Jun 15, 2006·Journal of Neurology·N TéllezX Montalban
Nov 7, 2006·Journal of Psychosomatic Research·Kirsten van Kessel, Rona Moss-Morris
Feb 13, 2007·International Journal of Rehabilitation Research. Internationale Zeitschrift Für Rehabilitationsforschung. Revue Internationale De Recherches De Réadaptation·Kadriye ArmutluRana Karabudak
Apr 6, 2007·Neurorehabilitation and Neural Repair·D KosS Ilsbroukx
Oct 2, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A LerdalA A Dahl
Mar 18, 2008·Journal of Neurology, Neurosurgery, and Psychiatry·S JohanssonL von Koch
Sep 23, 2008·Multiple Sclerosis : Clinical and Laboratory Research·D H MillerC H Polman
Nov 19, 2008·Sleep·Philipp O ValkoChristian R Baumann
Feb 3, 2009·Multiple Sclerosis : Clinical and Laboratory Research·E PatrickUNKNOWN New York State MS Consortium
Dec 3, 2009·Nature Reviews. Neurology·Alexandra DegenhardtGeorge C Ebers
Dec 8, 2009·Multiple Sclerosis : Clinical and Laboratory Research·Kimia Honarmand, Anthony Feinstein
Sep 8, 2010·Sleep·Tiffany J Braley, Ronald D Chervin
Mar 10, 2011·Annals of Neurology·Chris H PolmanJerry S Wolinsky
Jun 26, 2012·Multiple Sclerosis : Clinical and Laboratory Research·B WoodB V Taylor
Dec 19, 2013·Journal of Neurosciences in Rural Practice·Karthik NagarajRita Christopher
Jul 24, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Tessel F RuniaRogier Q Hintzen
Dec 24, 2014·Multiple Sclerosis : Clinical and Laboratory Research·Anthony Feinstein
Feb 28, 2015·Disease Markers·Arjan MalekzadehUNKNOWN TREFAMS-ACE Study Group
Oct 21, 2016·Acta Neurologica Scandinavica·S SimpsonI van der Mei
Feb 10, 2016·Multiple Sclerosis and Related Disorders·Bardia NourbakhshEmmanuelle Waubant
Feb 28, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Michele CavallariCharles Rg Guttmann

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Citations

Aug 10, 2020·Neurology. Neuroimmunology and Neuroinflammation·Tarun SinghalHoward L Weiner
Apr 8, 2019·Multiple Sclerosis and Related Disorders·Patricia StefancinTimothy Q Duong
Apr 18, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Ilaria CarpinellaDavide Cattaneo

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