Fatigue and fatigability in older adults

PM & R : the Journal of Injury, Function, and Rehabilitation
Basil Eldadah

Abstract

Fatigue is believed to be a common complaint among older adults; however, multiple studies of self-reported fatigue across the lifespan have found this may not be the case. To explain this paradox, this article considers "fatigability"-a phenotype characterized by the relationship between an individual's perceived fatigue and the activity level with which the fatigue is associated. Fatigability may be measured by combining self-report measures of fatigue with performance of physical or cognitive activities, provided that the work of the activity is known or can be standardized. Doing so prevents self-pacing and allows meaningful comparisons across subjects and between studies. Increased fatigability with aging may arise from a variety of factors including age-related changes in energy production or utilization, and inflammatory mechanisms. A few published intervention studies have targeted fatigue in older adults, though none have examined fatigability specifically. Because fatigue may represent a physiologic warning system, future clinical studies may benefit from a focus on fatigability, where both symptoms and function are considered.

References

Jan 1, 1990·Scandinavian Journal of Work, Environment & Health·G Borg
Aug 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·S Wessely, R Powell
Mar 1, 1988·Annals of Internal Medicine·G P HolmesS Pahwa
Jul 1, 1988·European Heart Journal·A Appels, P Mulder
Apr 1, 1995·Journal of Psychosomatic Research·E M SmetsJ C De Haes
Sep 1, 1995·Psychological Medicine·R Fuhrer, S Wessely
Sep 1, 1996·Scandinavian Journal of Social Medicine·K AvlundI Gause-Nilsson
Aug 8, 1998·International Journal of Nursing Studies·L J TiesingaR J Halfens
Jan 5, 1999·American Journal of Respiratory and Critical Care Medicine·J L HankinsonK B Fedan
Nov 27, 1999·Gait & Posture·R L Waters, S Mulroy
Jun 3, 2000·The European Respiratory Journal·J P JanssensL P Nicod
Aug 5, 2000·Clinics in Geriatric Medicine·E G Lakatta
Nov 4, 2000·Neurology·L B Krupp, L E Elkins
Mar 17, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·L P FriedUNKNOWN Cardiovascular Health Study Collaborative Research Group
Apr 3, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lucile CapuronAndrew H Miller
May 10, 2002·European Urology·M E BeuteE Brähler
Jan 22, 2003·Journal of the American College of Cardiology·Andrew M KatesRobert J Gropler
Mar 26, 2003·Biochemical Society Transactions·C Franceschi, M Bonafè
Sep 13, 2003·Journal of Applied Physiology·Margaret-Mary G Wilson, John E Morley
Sep 26, 2003·Psychosomatic Medicine·Kirsten AvlundMarianne Schroll
Nov 6, 2003·Journal of Applied Physiology·Alberto U FerrariMarco Centola
Mar 16, 2004·Journal of Psychosomatic Research·A J DittnerR G Brown
Mar 31, 2004·Sports Medicine·David W Russ, Jane A Kent-Braun
Nov 16, 2004·European Journal of Obstetrics, Gynecology, and Reproductive Biology·M E BeutelE Brähler
Jun 3, 2005·Metabolism: Clinical and Experimental·Wayne T WillisRichard M Herman
Jun 28, 2005·Cancer Letters·Devanand Sarkar, Paul B Fisher
Jul 29, 2005·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Chien-Ming Yang, Chih-Hsing Wu
Sep 17, 2005·Journal of Applied Physiology·Nicholas A RyanTimothy P Gavin
Nov 24, 2005·International Journal of Epidemiology·Vishal R AggarwalGary J Macfarlane
May 25, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Carmelinda Ruggiero, Luigi Ferrucci
Aug 1, 2006·Journal of Pain and Symptom Management·Cielito C Reyes-GibbyCharles S Cleeland
Sep 29, 2006·Sports Medicine·Romain MeeusenMaria F Piacentini
Nov 8, 2006·Brain, Behavior, and Immunity·Robert Dantzer, Keith W Kelley
Nov 11, 2006·Archives of Gerontology and Geriatrics·Kirsten Schultz-Larsen, Kirsten Avlund
Dec 15, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·UNKNOWN LIFE Study InvestigatorsStephanie Studenski
Feb 3, 2007·Journal of Psychosomatic Research·Chanaka WijeratneHenry Brodaty

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Citations

Jul 28, 2013·Journal of Palliative Medicine·Sara CombsJean S Kutner
Mar 28, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Stacey L SchepensSusan L Murphy
Dec 4, 2013·Aging Clinical and Experimental Research·Minna MäntyKirsten Avlund
Jan 17, 2014·Journal of Epidemiology and Community Health·Charlotte Juul NilssonRikke Lund
Oct 22, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Minna MäntyKirsten Avlund
Feb 18, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Benzi M KlugerJoseph Friedman
Feb 9, 2016·Experimental Gerontology·Anita D ChristieJane A Kent
Dec 10, 2013·The Journal of Nutritional Biochemistry·Gabriela Gutierrez-SalmeanIsrael Ramirez-Sanchez
Jan 1, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Heather E WhitsonCathleen S Colón-Emeric
Jul 27, 2010·PM & R : the Journal of Injury, Function, and Rehabilitation·Lynn H Gerber
Mar 5, 2013·Journal of the American Geriatrics Society·Robert A FieoKirsten Avlund
Jun 19, 2012·Journal of the American Geriatrics Society·Minna MäntyKirsten Avlund
Jan 15, 2014·Journal of the American Geriatrics Society·Eleanor M SimonsickLuigi Ferrucci
Aug 30, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Adam J SantanastoAnne B Newman
Jun 28, 2011·Archives of Physical Medicine and Rehabilitation·Karon F CookMark P Jensen
Jul 21, 2015·Experimental Gerontology·Elisa ZengariniMatteo Cesari
Jan 6, 2015·Journal of the American Geriatrics Society·Nancy W GlynnAnne B Newman
Sep 9, 2015·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Thorlene EgertonJorunn L Helbostad
Jan 7, 2014·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Feng LinMark Mapstone
Dec 27, 2011·Journal of Biomechanics·Roger M Enoka
Sep 6, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Catherine A RichardsonDawn C Mackey
Jun 3, 2016·Journal of the American Geriatrics Society·Eleanor M SimonsickLuigi Ferrucci
Jun 9, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Vincenzo ValianiTodd M Manini
Jan 23, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Eleanor M SimonsickLuigi Ferrucci
Aug 31, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Susan L MurphyStacey L Schepens Niemiec
Oct 19, 2016·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Patrick J BrownSteven P Roose
Sep 1, 2016·Archives of Physical Medicine and Rehabilitation·Melissa Shuman-ParetskyRoee Holtzer
Feb 16, 2017·International Journal of Geriatric Psychiatry·Patrick J BrownUNKNOWN Health ABC Study
Jul 31, 2013·The American Journal of Hospice & Palliative Care·Josef Finsterer, Sinda Zarrouk Mahjoub
Sep 6, 2018·Vox Sanguinis·Micah T ProchaskaDavid O Meltzer
Jul 15, 2017·Circulation. Heart Failure·Kilian WeissRobert G Weiss
Oct 14, 2018·Journal of the American Geriatrics Society·Eleanor M SimonsickNancy W Glynn
Nov 24, 2018·Journal of Aging and Health·Lotta PalmbergMerja Rantakokko
Apr 27, 2019·Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition·Nikhil BanerjeeBonnie E Levin
Aug 15, 2019·Journal of the American Heart Association·Yujia QiaoJennifer A Schrack
Nov 13, 2019·Sports Medicine·Nicolas Place, Guillaume Y Millet
Nov 17, 2019·International Journal of Environmental Research and Public Health·Hyerang Kim, Heesook Son
Dec 13, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Elizabeth A SalernoJennifer A Schrack
Jan 17, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jennifer A SchrackLuigi Ferrucci

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