PMID: 6408927Jul 1, 1983Paper

Fatigue and phosphocreatine depletion during carbon dioxide-induced acidosis in rat muscle

The American Journal of Physiology
K SahlinH Sjöholm

Abstract

Isolated extensor digitorum longus muscles from rat were exposed to atmospheres of 30% CO2 (high-CO2 muscles) or 6.5% CO2 (control muscles) in O2 for 95 min. Muscle contraction characteristics were studied before and after the incubation. Tetanic tension decreased in high-CO2 muscles to 55% of initial value but remained unchanged in control muscles. Relaxation time was prolonged in high-CO2 muscles but not in control muscles. Intracellular pH was 6.67 +/- 0.04 (SD) in high-CO2 muscles and 7.01 +/- 0.04 in control muscles. CO2-induced acidosis had a marked influence on the intermediary energy metabolism as shown by a fourfold increase of glucose 6-phosphate, a 14% increase of ADP, and a decrease of phosphocreatine to 44% of the control value. Lactate and pyruvate contents were unchanged. The observed metabolic changes can be explained by an effect of H+ on the activity of phosphofructokinase and on the creatine kinase equilibrium. It can be concluded that H+ concentration causes muscular fatigue. It is, however, uncertain whether this is an effect of increased H+ per se or by high-energy phosphate depletion induced by acidosis.

References

Nov 1, 1977·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·R C HarrisE Hultman
Aug 1, 1978·Canadian Journal of Physiology and Pharmacology·D W Fretthold, L C Garg
Jan 1, 1974·Pflügers Archiv : European journal of physiology·R N KhuriS K Agulian
Nov 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·I A Rose
Jan 1, 1970·Pflügers Archiv : European journal of physiology·J L PannierI Leusen
Apr 1, 1982·Acta Physiologica Scandinavica·J LännergrenB Johansson

❮ Previous
Next ❯

Citations

Mar 1, 1991·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·L M Satlin
Apr 1, 1987·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J al-DahanG B Haycock
Nov 1, 1984·Acta Physiologica Scandinavica·K Sahlin, J Henriksson
Nov 1, 1993·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·E Le RumeurJ D de Certaines
Oct 18, 2007·Pflügers Archiv : European journal of physiology·Jochen ZangeNorbert Maassen
Nov 12, 2014·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·R Todd AlexanderHenrik Dimke
Apr 14, 2016·Sports Medicine·Alireza NaderiMark E T Willems
Feb 1, 1989·Pflügers Archiv : European journal of physiology·A de HaanA J Sargeant
Jan 1, 1987·Acta Physiologica Scandinavica·K SahlinH Sjöholm
Jul 1, 1993·Pflügers Archiv : European journal of physiology·F DjouadiC Merlet-Bénichou
Dec 1, 1993·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·M Lelièvre-Pégorier, C Merlet-Bénichou
Jul 25, 2009·Clinical Physiology and Functional Imaging·Tessa A C NizetHans Th M Folgering
Dec 25, 2009·European Journal of Applied Physiology·Tyler A Churchward-VenneGreg D Marsh
Apr 6, 2017·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Melvin Bonilla-Félix
Jan 1, 1987·European Journal of Applied Physiology and Occupational Physiology·J HirvonenM Härkönen
Jan 1, 1991·European Journal of Applied Physiology and Occupational Physiology·A de HaanA J Sargeant
Aug 1, 1989·Muscle & Nerve·K Hainaut, J Duchateau
May 18, 1999·The American Journal of Physiology·W C O'Neill
Sep 20, 2002·Sports Medicine·Shaun McMahon, David Jenkins
Aug 1, 1997·Journal of Applied Physiology·O VerbitskyE Isakov
Aug 18, 2009·Clinical Science·William D-C ManMichael I Polkey
Mar 3, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Sevgi GurkanLisa M Satlin
Nov 11, 1999·American Journal of Respiratory and Critical Care Medicine·G F RaffertyJ Moxham
Feb 16, 2002·The Japanese Journal of Physiology·N AnzaiK Kawahara
Nov 21, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jyothsna Gattineni, Michel Baum
Dec 4, 2013·Nephron. Physiology·Katharina SchmidtSascha Bandulik
Jan 12, 2011·Pflügers Archiv : European journal of physiology·Sascha BandulikMarkus Reichold
Jan 15, 2010·Current Opinion in Pulmonary Medicine·Roberto A Rabinovich, Jordi Vilaró
Dec 9, 1998·The American Journal of Physiology·Y WangC M Wood
Sep 1, 1995·Comparative Biochemistry and Physiology. Part A, Physiology·C GeersG Gros
May 29, 1987·Biochemical and Biophysical Research Communications·M T ThébaultJ Y Le Gall

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.