Fatigue and the wear-off effect in adult patients with common variable immunodeficiency

Clinical and Experimental Immunology
Joud HajjarJ S Orange

Abstract

Patients with common variable immunodeficiency (CVID) have increased fatigue compared with the general population. Fatigue is associated with lower quality of life (QoL), which is associated with higher mortality in CVID. This study aimed to determine the prevalence of self-reported fatigue for patients with CVID and to identify its possible drivers and burden on QoL. We analysed data from the 2013 Immune Deficiency Foundation (IDF) treatment survey. Answers were included from 873 CVID patients who responded (respondents). Of the 873 respondents included in the analysis, 671 (76·9%) reported fatigue, of whom 400 (83·7%) were receiving intravenous (i.v.) immunoglobulins (IVIG) and 271 (68·6%) were receiving subcutaneous (s.c.) immunoglobulins. This difference in fatigue between patients receiving IVIG and SCIG was statistically significant (P < 0·001). Dose and frequency of immunoglobulin replacement therapy (IgGRT) did not affect fatigue prevalence. Fatigued patients on IVIG reported greater infection rates and required more anti-microbials during the wear-off period. Fatigued patients reported worse health status than non-fatigued patients, and had lower rates of employment, education, household income and school attendance th...Continue Reading

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Citations

Aug 5, 2019·Journal of Clinical Immunology·Carolyn BalohPatricia Lugar
Aug 3, 2019·Journal of Clinical Immunology·Frederik V IlkjærIsik S Johansen
Aug 27, 2019·Frontiers in Immunology·Mark R ZielinskiNoel R Rose
Jan 15, 2019·Clinical and Experimental Immunology·M BayrhuberA Nieters
Dec 1, 2020·Journal of Participatory Medicine·Shouling ZhangArtemio M Jongco Iii
Apr 13, 2020·The Journal of Allergy and Clinical Immunology. in Practice·Federica PulvirentiIsabella Quinti

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