Fatigue in early, intensively treated and tight-controlled rheumatoid arthritis patients is frequent and persistent: a prospective study

Rheumatology International
Margot J M WalterJ J Luime

Abstract

Fatigue has a large impact on quality of life and is still unmanageable for many patients. Study aims were describe (1) the prevalence and pattern of fatigue over time in patients with early rheumatoid arthritis under a treat-to-target strategy and (2) identify predictive factors for worsening and recovering of fatigue over time. Data from the tREACH study were used, comparing different treatment strategies with fatigue as secondary objective. Patient outcomes on fatigue, quality of life, depression, and coping were obtained every 6 months and clinically assessed every 3 months. Prediction of fatigue at 12 months was investigated with an ROC curve. Analysis was stratified into non-fatigue and fatigue at baseline. Logistic regression was used for the evolution of fatigue in relation with the covariates over time. Almost half of all patients (n = 246) had high fatigue levels at baseline, decreasing slightly over time. At 12 months, 43% of patients were fatigued; while 23% of the initially fatigued patients showed lower levels of fatigue, the fatigue level had increased in 15% of the initially non-fatigued patients. The strongest predictor of fatigue was the previous fatigue levels (AUC 0.89). Higher score on the depression scale ...Continue Reading

References

Jun 1, 1983·Acta Psychiatrica Scandinavica·A S Zigmond, R P Snaith
Nov 1, 1994·British Journal of Rheumatology·W van LankveldC van der Staak
Feb 8, 2002·Journal of Psychosomatic Research·Ingvar BjellandDag Neckelmann
Apr 3, 2003·Journal of Psychosomatic Research·Helen J MichielsenGuus L Van Heck
Aug 7, 2004·British Journal of Health Psychology·Jolanda De VriesMarjolein Drent
Feb 2, 2006·Rheumatology·L C PollardD L Scott
Oct 13, 2006·Chest·Helen J MichielsenJolanda De Vries
Oct 24, 2009·Arthritis Research & Therapy·Jaap Fransen, Piet L C M van Riel
Sep 8, 2010·Rheumatology·Sarah HewlettJohn Kirwan
Jan 22, 2013·Arthritis Care & Research·Stephanie NikolausMart A F J van de Laar
Apr 29, 2015·Clinical Psychology Review·F MatchamT Chalder
Oct 29, 2015·RMD Open·Hanna W van SteenbergenAnnette H M van der Helm-van Mil
Sep 1, 2017·Nature Reviews. Rheumatology·Lilian H D van Tuyl, Maarten Boers

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Citations

Aug 23, 2019·Rheumatology·Katie L Druce, Neil Basu
Aug 23, 2019·Rheumatology·Eduardo J F SantosRicardo J O Ferreira
Dec 28, 2019·Thyroid : Official Journal of the American Thyroid Association·Eyun SongWon Gu Kim
May 10, 2020·RMD Open·Janet E Pope
Aug 3, 2020·Arthritis & Rheumatology·Casper G Schoemaker, Maarten P T de Wit
Aug 28, 2020·Arthritis & Rheumatology·Melissa HoldrenUNKNOWN Canadian Early Arthritis Cohort investigators
Nov 10, 2021·Scandinavian Journal of Occupational Therapy·Margaret L SøvikTina Taule

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