Fatigue in multiple sclerosis: a look at the role of poor sleep

Frontiers in Neurology
Lauren B Strober

Abstract

Fatigue is a frequent and debilitating symptom of multiple sclerosis (MS) with rates ranging anywhere from 53 to 90%. Despite its high prevalence and grave impact on overall functioning and quality of life, the accurate definition, quantification, and etiology of fatigue have plagued the MS literature and clinical care for decades. With regard to its etiology, MS-related fatigue has been construed as being either primary or secondary. Primary fatigue is purported to be related to centrally mediated processes of the disease whereas secondary fatigue is thought to be a result of the host of factors that may accompany MS (e.g., depression, sleep disturbance). The present paper focuses on secondary fatigue and the role of sleep disturbance, in particular. Despite the intuitive assumption that sleep problems could contribute to fatigue, sleep problems in MS have gone fairly unrecognized until recently. The present paper provides a brief review of the literature pertaining to the prevalence and nature of sleep problems in MS as well as their association with fatigue. A replication of this author's and others work is presented further demonstrating that sleep disturbance is a significant contributor to fatigue in MS when taking into a...Continue Reading

References

Apr 1, 1988·Archives of Neurology·L B KruppL C Scheinberg
Jan 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J D FiskW F Schlech
Nov 1, 1995·Acta Neurologica Scandinavica·C ColosimoC Pozzilli
Aug 11, 1998·Journal of Personality Assessment·D L NyenhuisD C Garron
Aug 28, 1998·Journal of Psychosomatic Research·H FordM Johnson
Apr 25, 2000·Multiple Sclerosis : Clinical and Laboratory Research·J IriarteP Castro
Dec 12, 2002·Multiple Sclerosis : Clinical and Laboratory Research·P FlacheneckerK V Toyka
Sep 11, 2003·International Journal of Nursing Studies·Gullvi FlensnerOlle Söderhamn
Apr 21, 2004·Archives of Neurology·Hrayr P AttarianAnne H Cross
Mar 31, 2005·Seminars in Neurology·W Elon Fleming, Charles P Pollak
May 17, 2005·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Lauren B Strober, Peter A Arnett
Oct 1, 2005·Multiple Sclerosis : Clinical and Laboratory Research·Megan M Smith, Peter A Arnett
Aug 12, 2006·Multiple Sclerosis : Clinical and Laboratory Research·B R StantonE Silber
Nov 23, 2006·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·H KaynakA Siva
Oct 19, 2007·Multiple Sclerosis : Clinical and Laboratory Research·M ManconiM Filippi
Jan 16, 2008·QJM : Monthly Journal of the Association of Physicians·R J Mills, C A Young
Nov 26, 2008·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·N C V MoreiraV M S de Bruin
Nov 3, 2009·Sleep Medicine Reviews·Steven D BrassSanford Auerbach
Feb 1, 2011·Multiple Sclerosis : Clinical and Laboratory Research·C VeauthierJ P Sieb
Dec 21, 2011·Multiple Sclerosis : Clinical and Laboratory Research·M KaminskaD A Trojan
Aug 24, 2012·Multiple Sclerosis : Clinical and Laboratory Research·I CôtéR J Kimoff
Sep 13, 2012·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Nuray Dayapoğlu, Mehtap Tan
Oct 31, 2012·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Anna Pokryszko-DraganKatarzyna Konieczna
Dec 5, 2012·Acta Neurologica Scandinavica. Supplementum·H M B LundeL Bø
Jan 15, 2013·Multiple Sclerosis International·Tiffany J BraleyBenjamin M Segal
Jun 15, 2013·Clinical Neurology and Neurosurgery·Christian VeauthierFriedemann Paul
Nov 20, 2013·Multiple Sclerosis International·Ulf KallweitPhilipp O Valko
Feb 18, 2014·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Tiffany J BraleyRonald D Chervin
Aug 2, 2014·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Jian-Hua ChenYan Huang

❮ Previous
Next ❯

Citations

Feb 11, 2016·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Jone Furlund OweOle-Bjørn Tysnes
Jan 1, 2015·Nature Reviews. Disease Primers·Charles R M BanghamGraham P Taylor
Jun 12, 2016·Neuro-oncology·Terri S ArmstrongAnn M Berger
Nov 12, 2013·Trends in Neurosciences·Lisa GenzelFrancesco P Battaglia
Nov 9, 2016·Journal of the Neurological Sciences·Viviana NocitiGiacomo Della Marca
Jun 14, 2017·Multiple Sclerosis Journal - Experimental, Translational and Clinical·Mayis AldughmiCatherine F Siengsukon
Dec 16, 2016·Sleep & Breathing = Schlaf & Atmung·Michael LinDanny J Eckert
Jun 14, 2017·Multiple Sclerosis Journal - Experimental, Translational and Clinical·Catherine F SiengsukonSandra Billinger
Dec 20, 2017·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Viral P Patel, Anthony Feinstein
Jul 24, 2020·Sleep & Breathing = Schlaf & Atmung·Alia A AlghwiriSusan L Whitney
Feb 25, 2021·Nature and Science of Sleep·Michelle DrerupAmy B Sullivan
Apr 1, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Michelle F Devine, Erik K St Louis
Apr 9, 2021·BMC Neurology·Lily Yuen Wah HoShamay Sheung Mei Ng
Aug 16, 2021·Multiple Sclerosis and Related Disorders·Katie L J CederbergRobert W Motl
May 13, 2017·Disability and Health Journal·Catherine F SiengsukonSandra Billinger

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists
Lauren B Strober, Peter A Arnett
© 2022 Meta ULC. All rights reserved