Fatigue in Patients With Advanced Terminal Cancer Correlates With Inflammation, Poor Quality of Life and Sleep, and Anxiety/Depression

The American Journal of Hospice & Palliative Care
Alex Rua RodriguesAuro Del Giglio

Abstract

To assess which laboratory and clinical factors are associated with fatigue in patients with terminal cancer. We evaluated 51 patients with advanced incurable solid tumors using the Chalder Fatigue Questionnaire (CFQ) and the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) scale for fatigue; the Pittsburgh Sleep Quality Index (PSQI-BR) for sleep quality; the Hospital Anxiety and Depression Scale (HADS) for anxiety and depression; the European Organization for Research and Treatment of Cancer (EORTC) Core Quality of Life Questionnaire, Version 3.0 (QLQ C-30); and Functional Assessment of Cancer Therapy (FACT) for quality of life. We also analyzed several inflammatory markers and the modified Glasgow prognostic score (mGPS). We observed severe fatigue in 19 (38%) patients (FACIT-F score >36). There was a significant correlation between fatigue as evaluated by the CFQ and quality of sleep and between the CFQ mental fatigue subscale scores and TNF-α level. When fatigue was evaluated using the FACIT-F scale, we observed a significant association between fatigue and anxiety/depression, quality of sleep, mGPS, and hemoglobin levels. Fatigue measured both with the CFQ and FACIT-F scale correlated with poor quality of...Continue Reading

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Citations

Sep 20, 2017·Scandinavian Journal of Occupational Therapy·Jesper Larsen MaerskKaren la Cour
Apr 13, 2017·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Xiao Jun WangAlexandre Chan
Jul 10, 2020·Wiener klinische Wochenschrift·Gudrun PiringerJosef Thaler
Nov 4, 2020·Palliative & Supportive Care·Huda Anshasi, Muayyad Ahmad
Feb 4, 2021·The American Journal of Hospice & Palliative Care·Laurence Lean Chin TanJames Alvin Low
Jan 23, 2021·Critical Reviews in Oncology/hematology·Rebekah PattonBarry J A Laird
Jul 3, 2021·Medical Sciences : Open Access Journal·Eida M Castro-FigueroaGuillermo N Armaiz-Peña

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