Fatigue in patients with inflammatory bowel disease is associated with distinct differences in immune parameters

Clinical and Experimental Gastroenterology
Lauran VogelaarC Janneke van der Woude

Abstract

Although it is well recognized that fatigue is an important problem in many of the quiescent inflammatory bowel disease (IBD) patients, it is unknown whether the immune status is different in fatigued versus non-fatigued patients. In this study, we contrasted various characteristics of the immune system in fatigued against non-fatigued patients with IBD in clinical remission. Patients with IBD in clinical remission were phenotyped according to the Montreal classification, and the checklist individual strength-fatigue (CIS-fatigue) was used to assess fatigue (CIS-fatigue ≥ 35). Flow cytometry on peripheral blood samples was used to investigate differences in leukocyte subsets. The expression of various cytokines was determined in stimulated whole blood and serum samples using enzyme-linked immunosorbent assay. Differences between fatigued and non-fatigued patients with IBD were assessed. In total, 55 patients were included in the fatigue group (FG) and 29 patients in the non-fatigue group (NFG). No differences in demographic and clinical characteristics were observed between the groups. Flow cytometry data showed a significantly lower percentage of monocytes (p = 0.011) and a higher percentage of memory T-cells (p = 0.005) and n...Continue Reading

Citations

Aug 31, 2017·Clinical Reviews in Allergy & Immunology·Pieter HindryckxSilvio Danese
Nov 25, 2019·Advances in Therapy·Angelica NocerinoArun Swaminath
May 14, 2020·Current Opinion in Gastroenterology·Taha Qazi
Jun 1, 2018·Inflammatory Bowel Diseases·Jessica Elia, Sunanda Kane
Dec 12, 2018·Nature Reviews. Gastroenterology & Hepatology·Nienke Z BorrenAshwin N Ananthakrishnan
Jan 30, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Zobair M YounossiZachary Goodman
Mar 30, 2021·World Journal of Gastroenterology : WJG·Shan-Shan GongJing Zhao
Jul 7, 2021·Alimentary Pharmacology & Therapeutics·Jordan J McGingGordon W Moran
Jul 19, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Zobair M YounossiUNKNOWN RandomizEd Global Phase 3 Study to Evaluate the Impact on NASH with FibRosis of Obeticholic Acid TreatmEnt Study Investigato
Nov 23, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Henri BraatMaikel P Peppelenbosch
May 22, 2019·Inflammatory Intestinal Diseases·Kristina AluzaiteMichael Schultz

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
flow cytometry
biopsies

Software Mentioned

FlowJo
Stata
SPSS

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