Fatigue in Prevalent Haemodialysis Patients Predicts All-cause Mortality and Kidney Transplantation

Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine
Federica PicarielloJoseph Chilcot

Abstract

Fatigue affects between 49% and 92% of dialysis patients with considerable repercussions on their functioning and quality of life. To evaluate whether fatigue severity and its impact on functioning predict survival (all-cause mortality) and time to transplantation among in-centre haemodialysis patients. As part of a prospective study of fatigue among in-centre haemodialysis patients, survival data were collected between April 2014 and August 2017. Fatigue severity was measured using the Chalder Fatigue Questionnaire (CFQ) and fatigue-related functional impairment using the Work and Social Adjustment Scale (WSAS). Sociodemographic, clinical, and psychological data were collected. The association between fatigue and outcomes was assessed using proportional hazard survival models, allowing for competing risks, and discrete-time survival models. All models were adjusted for relevant risk factors. The sample consisted of 174 haemodialysis patients. There were 37 deaths and 31 transplantations over 3 years. At 1,095 days (36 months), cumulative survival was 70.5% and the cumulative transplantation rate was 22.2%. In unadjusted models, fatigue was significantly associated with an increased risk of death (CFQ-continuous SHR = 1.06, 95%...Continue Reading

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Citations

Aug 23, 2019·International Journal of Palliative Nursing·Antonia Dean
Nov 20, 2019·British Journal of Health Psychology·Federica PicarielloJoseph Chilcot
Dec 8, 2020·American Journal of Physiology. Renal Physiology·Danielle L KirkmanAntonio Abbate
Oct 18, 2020·Journal of Pain and Symptom Management·Federica PicarielloJoseph Chilcot
Apr 30, 2021·BMC Nephrology·Zakariya Al NaamaniMohammed Al Maqbali

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