Fatigue in Primary Sjögren's Syndrome: Clinical, Laboratory, Psychometric, and Biologic Associations.

Arthritis Care & Research
Theofanis KarageorgasClio P Mavragani

Abstract

To identify independent contributors of fatigue in primary Sjögren's syndrome (SS) patients, taking into account clinical, laboratory, and psychological features, and to explore the potential role of interferon (IFN)-induced gene indoleamine 2,3-dioxygenase (IDO-1), anti-21-hydroxylase (anti-21[OH]) antibodies, and soluble BAFF. Detailed clinical and laboratory characteristics were recorded for 106 primary SS patients. The Functional Assessment of Chronic Illness Therapy-Fatigue, Zung Depression Scale, State-Trait Anxiety Inventory, Eysenck Personality Questionnaire Scale, and Athens Insomnia Scale were adopted to assess fatigue, depression, anxiety, and sleep disturbances, respectively. Peripheral whole blood expression levels of IDO-1, as well as type I and II IFN-induced genes were calculated using quantitative reverse transcriptase-polymerase chain reaction. Serum anti-21(OH) antibodies and soluble BAFF levels were determined by a radioimmunoassay and an enzyme-linked immunosorbent assay, respectively. Univariate and multivariate models were performed to identify determinants of fatigue. Fatigue was detected in 32 of 106 (30.2%) primary SS patients. In univariate analysis, fatigue was associated with arthralgias/myalgias, f...Continue Reading

References

Dec 1, 1993·British Journal of Rheumatology·B GudbjörnssonR Hällgren
Sep 19, 1998·Annals of the Rheumatic Diseases·P J BarendregtH M Markusse
Oct 18, 2000·Journal of Psychosomatic Research·C R SoldatosT J Paparrigopoulos
Feb 7, 2002·Annals of the Rheumatic Diseases·H I BaxW W I Kalk
May 15, 2002·Annals of the Rheumatic Diseases·C VitaliUNKNOWN European Study Group on Classification Criteria for Sjögren's Syndrome
Feb 4, 2003·The American Journal of Psychiatry·Niloofar Afari, Dedra Buchwald
Jan 1, 1965·Archives of General Psychiatry·W W ZUNG
Oct 15, 2003·Arthritis and Rheumatism·Britta StrömbeckLennart T H Jacobsson
Sep 14, 2004·Annals of the Rheumatic Diseases·A HartkampR H W M Derksen
Dec 14, 2004·Arthritis and Rheumatism·Kyriakos A KirouMary K Crow
Oct 20, 2007·Journal of Affective Disorders·Rosa Bellmann-WeilerGuenter Weiss
Nov 28, 2008·Arthritis and Rheumatism·Barbara SegalKathy Moser
Nov 12, 2009·Autoimmunity Reviews·Clio P Mavragani, Haralampos M Moutsopoulos
Feb 12, 2010·Rheumatology·Wan-Fai Ng, Simon J Bowman
Aug 3, 2010·Journal of Autoimmunity·Clio P Mavragani, Mary K Crow
Oct 15, 2011·Arthritis Research & Therapy·Karstein HaldorsenJohan Gorgas Brun
Jun 15, 2012·Journal of Autoimmunity·Clio P MavraganiHaralampos M Moutsopoulos
Aug 31, 2012·Arthritis and Rheumatism·Clio P MavraganiHaralampos M Moutsopoulos
Sep 13, 2012·The Journal of Clinical Psychiatry·Marc UdinaRocío Martín-Santos
Sep 13, 2012·Melanoma Research·Dorothée NashanSanjiv S Agarwala
Oct 10, 2012·Proceedings of the National Academy of Sciences of the United States of America·John C HallAntony Rosen
Nov 1, 2012·Arthritis Care & Research·Katie L HackettWan-Fai Ng
Jun 14, 2013·Annals of the Rheumatic Diseases·Dennis LendremUNKNOWN UK primary Sjögren's Syndrome Registry
Dec 18, 2013·Arthritis Care & Research·Anne Marit MengshoelRoald Omdal
Jan 21, 2014·Annals of the Rheumatic Diseases·Raphaèle SerorUNKNOWN EULAR Sjögren's Task Force

❮ Previous
Next ❯

Citations

Feb 28, 2016·Innate Immunity·Kjetil BårdsenRoald Omdal
Nov 28, 2018·Investigative Ophthalmology & Visual Science·Masahiko AyakiKazuno Negishi
Jan 3, 2019·Genomics & Informatics·Seunghee ChaKyudong Han
Mar 1, 2019·Rheumatology·Roald OmdalKatrine Brække Norheim
Jul 8, 2016·Nature Reviews. Disease Primers·Pilar Brito-ZerónManuel Ramos-Casals
Feb 21, 2018·The Korean Journal of Internal Medicine·Sang Wan ChungYun Jong Lee
Dec 14, 2018·International Journal of Molecular Sciences·Fabíola Reis de OliveiraEduardo Melani Rocha
Mar 14, 2019·Frontiers in Immunology·Iris L A BodewesMarjan A Versnel
Oct 17, 2017·Rheumatology Advances in Practice·Solveig K HammondsRoald Omdal
Dec 25, 2019·ACR Open Rheumatology·Claudio VitaliAntonio Puccetti
Feb 2, 2018·Therapeutic Advances in Musculoskeletal Disease·Nicoletta Del Papa, Claudio Vitali
Apr 22, 2020·Postgraduate Medicine·Muruga LoganathanSteven Lippmann
Oct 3, 2021·Nature Reviews. Rheumatology·Kristen DaviesWan-Fai Ng
Nov 14, 2021·Sleep & Breathing = Schlaf & Atmung·Emine KarabulBenan Musellim

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.