Fatigue independently predicts different work disability dimensions in etanercept-treated rheumatoid arthritis and ankylosing spondylitis patients

Arthritis Research & Therapy
Katie L DruceNeil Basu

Abstract

Work disability remains a significant problem in ankylosing spondylitis (AS) and rheumatoid arthritis (RA), despite biological therapy. This study aimed to test the hypothesis that the prevalent symptom of fatigue longitudinally predicts work disability among RA and AS patients commencing etanercept. Two observational studies, comprising RA and AS etanercept commencers, respectively, were analysed. Both provided data on work disability over 1 year and a comprehensive set of putative predictors, including fatigue. A series of repeated measures models were conducted, including baseline variables, visit (6/12 months), and the interaction between visit and each of the explanatory variables. A total of 1003 AS and 1747 RA patients were assessed. For AS, fatigue was significantly associated with presenteeism (linear mixed model coefficient 3.75, 95% confidence interval (CI) 2.14 to 5.36) and activity impairment (2.62, 1.26 to 3.98), but not with work productivity loss (1.81, -0.40 to 4.02) or absenteeism (generalised linear mixed model odds ratio (OR) 1.18, 95% CI 0.92 to 1.51). In RA, fatigue was associated with presenteeism (coefficient 3.44, 95% CI 2.17 to 4.70), activity impairment (1.52, 0.79 to 2.26), work productivity loss (4....Continue Reading

References

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Citations

Aug 23, 2019·Rheumatology·Eduardo J F SantosRicardo J O Ferreira
Oct 22, 2020·Current Medical Research and Opinion·Wei ZhouChen Dong
Jun 1, 2020·Best Practice & Research. Clinical Rheumatology·Emma DuresJette Primdahl
Aug 10, 2021·Work : a Journal of Prevention, Assessment, and Rehabilitation·Doxa Papakonstantinou

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Methods Mentioned

BETA
cognitive behavioural therapies
cognitive behavioural therapy

Clinical Trials Mentioned

NCT00544557
NCT00488475

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