Fatigue measurements in patients with primary biliary cirrhosis and the risk of mortality during follow-up

Liver International : Official Journal of the International Association for the Study of the Liver
Einar BjörnssonRoberta Jorgensen

Abstract

Fatigue was recently suggested to predict an increased risk of mortality in a primary biliary cirrhosis (PBC) cohort during follow-up. To analyse the impact of fatigue on prognosis in PBC. Patients with PBC who had earlier completed the fatigue impact scale (FIS) were identified. Prognosis in terms of death and liver transplantation (Tx) was determined. FIS values at baseline were analysed from 208 patients (192 females; median age 59 years (interquartile range 51-67), median follow-up of 5 years. Overall, 181 patients were alive at follow-up, 22 (12%) died and five (2.4%) underwent transplantation. FIS at baseline was 28 (12-47) and FIS at follow-up was 25 (8-64) (P<0.001; r=0.69). Among survivors, FIS at baseline was 27 (12-43), 36 (12-72) in those who died (P=0.059) and 99 (41-102) in those who underwent transplantation (P=0.0008). FIS at baseline was 44 (12-88) in patients with death and/or Tx vs. 27 (12-43) in survivors (P=0.003). Age [hazard ratio (HR) 1.1 (confidence interval (CI) 1.0-1.2)] and aspartate aminotransferase [HR 2.0 (CI 1.3-3.0)] were independently associated with decreased survival on multivariate analysis. FIS scores over 40 [HR 9.6 (CI 2.3-39.7)] and bilirubin [HR 4.8 (CI 2.8-8.2)] were independently asso...Continue Reading

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Citations

Apr 5, 2011·Clinics and Research in Hepatology and Gastroenterology·Marco Carbone, James Neuberger
Aug 5, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nadya Al-HarthyGideon M Hirschfield
Dec 2, 2015·Clinics and Research in Hepatology and Gastroenterology·Joanna Raszeja-WyszomirskaPiotr Milkiewicz
Sep 15, 2015·Lancet·Elizabeth J CareyKeith D Lindor
Nov 11, 2014·Expert Review of Clinical Immunology·Ahmad H AliKeith D Lindor
Jul 28, 2017·Clinical and Translational Gastroenterology·Victoria A L MosherBradley G Goodyear
Oct 27, 2018·Clinical Transplantation·Marcin KrawczykJoanna Raszeja-Wyszomirska
May 12, 2010·Nature Reviews. Gastroenterology & Hepatology·Ghulam AbbasKeith D Lindor
Oct 26, 2011·Journal of Clinical Nursing·Li-Jan WuJen-Chen Tsai
Feb 9, 2021·Journal of Translational Autoimmunity·Lorenzo MontaliPietro Invernizzi

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