PMID: 475Nov 1, 1975

Fatty acid and ketone body metabolism in the rat: response to diet and exercise

The Journal of Nutrition
E W AskewR L Huston

Abstract

This study was designed to measure the response of key enzymes of ketone body metabolism in heart, skeletal muscle, and liver to diet and exercise, two conditions known to influence ketone body utilization. A 3 (diet: control, high fat, or high carbohydrate) X 2 (kill condition: rested or exhausted) X 2 (training: trained or untrained) factorial design was used to estimate main experimental effects as well as identify significant interactions of the variables. Physical training (treadmill running) was associated with a doubling of the activity of skeletal muscle 3-oxoacid CoA transferase, a key enzyme in extrahepatic ketone body utilization. The activity of the rate-limiting enzyme of liver ketone body production, hydroxymethylglutaryl CoA synthetase (HMG CoA synthetase), was not greatly influenced by training or exhuastive exercise indicating that the metabolic control of the ketosis of exercise may more likely be a function of the supply of fatty acids to the liver rather than the activity of HMG CoA synthetase. Feeding a high fat diet, on the other hand, significantly increased the activity of liver HMG CoA synthetase, indicating that the ketosis of fat feeding may be of a different nature than that of exercise. The results ...Continue Reading

Citations

Jan 1, 1989·European Journal of Applied Physiology and Occupational Physiology·J H Adams, J H Koeslag
Jan 1, 1989·European Journal of Applied Physiology and Occupational Physiology·P SatabinJ Peret
Jul 20, 2016·Sports Medicine·Philippe J M PinckaersLuc J C van Loon
Dec 1, 1994·Journal of the American College of Nutrition·M Pacheco-Sánchez, K K Grunewald
Mar 22, 2016·Physiological Reports·Mark Christian C ManioTohru Fushiki
Aug 22, 2017·Cellular and Molecular Life Sciences : CMLS·Paishiun Nelson HsiehMukesh Kumar Jain
Jul 21, 2019·Lasers in Medical Science·Letícia Parada MoreiraLandulfo Silveira
Feb 1, 1976·Nutrition Reviews
Jan 8, 1998·Endocrinology·R B HarrisJ J Zachwieja
Jan 13, 2018·Nature Reviews. Neuroscience·Mark P MattsonAiwu Cheng
Jul 28, 2019·The American Journal of Clinical Nutrition·Matthew Sherrier, Hongshuai Li
Jun 1, 1991·The American Journal of Physiology·F Haddad, K M Baldwin

Related Concepts

Acetyl-CoA C-Acetyltransferase
CoASH
Cytochrome c Oxidase Subunit VIa
Dietary Carbohydrates
Ghee
Saturated Fat
Hydroxymethylglutaryl-CoA Synthase
Keto Acids
Ketone Bodies
Ketonuria

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