Fatty acid-binding protein 4 (FABP4) and FABP5 modulate cytokine production in the mouse thymic epithelial cells.

Histochemistry and Cell Biology
Yasuhiro AdachiYuji Owada

Abstract

Thymic stromal cells, including cortical thymic epithelial cells (cTEC) produce many humoral factors, such as cytokines and eicosanoids to modulate thymocyte homeostasis, thereby regulating the peripheral immune responses. In this study, we identified fatty acid-binding protein (FABP4), an intracellular fatty acid chaperone, in the mouse thymus, and examined its role in the control of cytokine production in comparison with FABP5. By immunofluorescent staining, FABP4(+) cells enclosing the thymocytes were scattered throughout the thymic cortex with a spatial difference from the FABP5(+) cell that were distributed widely throughout the cTEC. The FABP4(+) cells were immunopositive for MHC class II, NLDC145 and cytokeratin 8, and were identified as part of cTEC. The FABP4(+) cells were identified as thymic nurse cells (TNC), a subpopulation of cTEC, by their active phagocytosis of apoptotic thymocytes. Furthermore, FABP4 expression was confirmed in the isolated TNC at the gene and protein levels. To explore the function of FABP in TNC, TSt-4/DLL1 cells stably expressing either FABP4 or FABP5 were established and the gene expressions of various cytokines were examined. The gene expression of interleukin (IL)-7 and IL-18 was increase...Continue Reading

References

May 1, 1988·European Journal of Immunology·T ItohS Kasahara
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·C R HuntB M Spiegelman
Aug 1, 1984·Cellular Immunology·E van VlietW van Ewijk
Jun 1, 1984·European Journal of Immunology·E Van VlietW Van Ewijk
Apr 1, 1995·The Journal of Experimental Medicine·U von Freeden-JeffryR Murray
Jan 29, 1993·Biochemical and Biophysical Research Communications·G SiegenthalerJ H Saurat
Jan 1, 1996·Annual Review of Immunology·G AndersonE J Jenkinson
Aug 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·K J HareG Anderson
Jan 31, 2002·Histochemistry and Cell Biology·Yuji OwadaHisatake Kondo
Mar 5, 2002·The Journal of Investigative Dermatology·Yuji OwadaHisatake Kondo
Mar 19, 2003·International Review of Cytology·Jerry C Guyden, Mark Pezzano
Nov 14, 2003·Histochemistry and Cell Biology·Noriko KitanakaHisatake Kondo
May 25, 2004·Blood·Nahed El KassarRonald E Gress
Jul 6, 2004·Progress in Lipid Research·Norbert H Haunerland, Friedrich Spener
Feb 25, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Masaki MiyazakiMasamoto Kanno
Jul 20, 2005·Proceedings of the National Academy of Sciences of the United States of America·Susanna M MüllerHans-Reimer Rodewald
Sep 9, 2005·Current Opinion in Lipidology·Liza Makowski, Gökhan S Hotamisligil
Feb 17, 2006·European Journal of Immunology·Steffen MassaAntonius G Rolink
May 11, 2006·Biochemical and Biophysical Research Communications·Noriko KitanakaHisatake Kondo
Nov 18, 2006·Molecular and Cellular Biochemistry·Soha Abdelkawi AbdelwahabHisatake Kondo
Jun 9, 2007·European Journal of Immunology·Gili HartIdit Shachar
Nov 10, 2007·Nature Reviews. Immunology·Graham AndersonEric J Jenkinson
Aug 6, 2008·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Noriko YamamotoYuji Owada
Mar 26, 2009·Pharmacology & Therapeutics·Renata GorjãoRui Curi
May 27, 2010·Nutrition Reviews·Rebecca WallCatherine Stanton

❮ Previous
Next ❯

Citations

May 12, 2017·Molecular & Cellular Proteomics : MCP·Yunki Y YauValerie C Wasinger
Aug 15, 2014·The Journal of Nutrition·Ariful IslamYuji Owada
Jan 27, 2019·Molecular Neurobiology·Ariful IslamYuji Owada
May 10, 2013·Current Opinion in Clinical Nutrition and Metabolic Care·Philip C Calder
Jan 9, 2019·Data in Brief·Giuseppe FlorestaAntonio Rescifina
Aug 8, 2019·The Annals of Applied Statistics·Andrew McDavidMathias Drton

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.