Fatty acid-binding proteins in Echinococcus spp.: the family has grown

Parasitology Research
Jorge L PórfidoGisela R Franchini

Abstract

Fatty acid-binding proteins (FABPs) are small intracellular proteins that reversibly bind fatty acids and other hydrophobic ligands. In cestodes, due to their inability to synthesise fatty acids de novo, FABPs have been proposed as essential proteins, and thus, as possible drug targets and/or carriers against these parasites. We performed data mining in Echinococcus multilocularis and Echinococcus granulosus genomes in order to test whether this family of proteins is more complex than previously reported. By exploring the genomes of E. multilocularis and E. granulosus, six genes coding for FABPs were found in each organism. In the case of E. granulosus, all of them have different coding sequences, whereas in E. multilocularis, two of the genes code for the same protein. Remarkably, one of the genes (in both cestodes) encodes a FABP with a C-terminal extension unusual for this family of proteins. The newly described genes present variations in their structure in comparison with previously described FABP genes in Echinococcus spp. The coding sequences for E. multilocularis were validated by cloning and sequencing. Moreover, differential expression patterns of FABPs were observed at different stages of the life cycle of E. multilo...Continue Reading

References

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Citations

Jun 18, 2020·Pathogens·João Antonio DebarbaArnaldo Zaha
Jul 1, 2021·Parasitology·Andrew Hemphill, Britta Lundstroem-Stadelmann

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Datasets Mentioned

BETA
MN809107
MN809108
MN809109
MN809110
MN809111
MN809112
PS00214
PR00178
AF321119.1
AF321117.1

Methods Mentioned

BETA
RNAseq
PCR

Software Mentioned

MEGA7
BLASTN
BLASTX
BLASTP
HTSeqCount
PSIPRED
Hisat2
TBLASTN
Mega
CLUSTALW

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