Fatty acid changes in rat brain ethanolamine phosphoglycerides during and following chronic exposure to trichloroethylene

Toxicology and Applied Pharmacology
T KyrklundK G Haglid

Abstract

Rats were exposed by continuous inhalation to a moderate level of trichloroethylene (1720 mg/m3). The fatty acid pattern of brain ethanolamine phosphoglycerides was examined during exposure and after an additional exposure-free period. Alterations in the fatty acid pattern were noted after 30 days of exposure. An increased ratio of linoleic acid-derived (n-6) to linolenic acid-derived (n-3) fatty acids was observed in the cerebral cortex, the hippocampus, and the brain stem. Of the major fatty acids, arachidonic acid (20:4(n-6)) was increased in the cerebral cortex and the brain stem, while docosahexenoic acid (22:6(n-3)) was decreased in the cerebral cortex and the hippocampus. A further change in these fatty acids was observed in the cerebral cortex following a longer exposure period of 90 days. The 22-carbon linoleic acid-derived fatty acids were also increased after 90 days of exposure. These findings imply that trichloroethylene affects the metabolism of ethanolamine phosphoglyceride fatty acids in the rat brain by inhibiting desaturation of the linolenic acid family and by increasing desaturation of the linoleic acid family. The effect of trichloroethylene was partially reversible, since a postexposure solvent-free period...Continue Reading

Citations

Jun 1, 1991·Journal of Applied Toxicology : JAT·F Kössler
Aug 1, 1987·Toxicology·T KyrklundK Haglid
Dec 14, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P RidgwayJ-P Leach
Feb 1, 1991·Pharmacology & Toxicology·T Kyrklund, K Haglid
Jul 1, 1994·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·T Okamoto, K Shiwaku
Jan 1, 1988·Journal of Biochemical Toxicology·C P Le Bel, R A Schatz

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