Fatty acid composition and fatty acid binding protein expression in the postmortem frontal cortex of patients with schizophrenia: A case-control study

Schizophrenia Research
Kei HamazakiTakeo Yoshikawa

Abstract

Abnormal levels of n-3 polyunsaturated fatty acids (PUFAs), particularly docosahexaenoic acid (DHA), have been found in the postmortem frontal cortex, particularly the orbitofrontal cortex, of patients with schizophrenia. Altered mRNA expression of fatty acid binding protein (FABP) 5 and FABP7 has likewise been reported. This study investigated whether PUFAs in the frontal cortex [Brodmann area (BA) 8] and mRNA expression of FABP3, 5, and 7 were different between patients with schizophrenia (n=95) and unaffected controls (n=93). In contrast to previous studies, no significant differences were found in DHA between the groups. Although arachidonic acid (AA) levels were significantly decreased in the schizophrenia group, no association was found between AA and schizophrenia on logistic regression analysis. Only FABP3 expression was significantly lower in the schizophrenia group than in the control group. Significant inverse associations were seen between only two saturated fatty acids, behenic acid and lignoceric acid, and FABP3 expression. We found no evidence that major PUFA levels in BA8 are involved in the etiology of schizophrenia. Although FABP3 expression was not correlated with any of the major PUFAs, it might play a novel...Continue Reading

References

Oct 15, 1991·Biological Psychiatry·D F HorrobinM Glen
Feb 1, 1995·Brain Research. Molecular Brain Research·A E KingsburyC D Marsden
Apr 1, 1996·The American Journal of Psychiatry·C HillD Copolov
Dec 14, 2002·Journal of the American College of Nutrition·Artemis P Simopoulos
Nov 19, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·D R EvansS P Mahadik
Sep 29, 2004·Biological Psychiatry·Mingming HuanTomohito Hamazaki
Dec 30, 2006·The Journal of Clinical Psychiatry·Marlene P FreemanAndrew L Stoll
Nov 16, 2007·PLoS Biology·Akiko WatanabeTakeo Yoshikawa
Dec 13, 2007·Nature Reviews. Neuroscience·Robert DantzerKeith W Kelley
Oct 11, 2008·Brain and Cognition·Gillian A O'Driscoll, Brandy L Callahan
Dec 10, 2008·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Robert K McNamaraGhanshyam N Pandey
Jun 22, 2010·The International Journal of Developmental Biology·Rong-Zong LiuRoseline Godbout
Aug 10, 2010·Journal of Affective Disorders·Kalpana Poudel-TandukarUNKNOWN Japan Public Health Center-based Prospective Study Group
Jan 14, 2012·Current Pharmaceutical Design·Nilufar MossahebG Paul Amminger
Mar 1, 2012·Journal of Clinical Psychopharmacology·Paolo Fusar-Poli, Gregor Berger
Sep 18, 2012·Schizophrenia Research·W J M van der KempH E Hulshoff Pol
Feb 23, 2013·Journal of Psychiatric Research·Ameer Y TahaJagadeesh S Rao

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Citations

Nov 9, 2016·European Psychiatry : the Journal of the Association of European Psychiatrists·K HamazakiT Yoshikawa
Jun 28, 2019·Frontiers in Psychiatry·Maximus BergerG Paul Amminger
Sep 27, 2018·Alzheimer's Research & Therapy·Umesh GangishettiWilliam T Hu
Oct 10, 2018·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Kohji FukunagaKazuya Matsuo
Dec 2, 2019·Archives of Pharmacal Research·Seong-Eun LeeGum Hwa Lee
Dec 4, 2016·European Archives of Psychiatry and Clinical Neuroscience·Wolfgang JordanJohann Steiner
Aug 9, 2020·The American Journal of Clinical Nutrition·Kei HamazakiUNKNOWN Japan Environment and Children's Study Group
Feb 9, 2021·Oxidative Medicine and Cellular Longevity·Evgeny A ErmakovLiudmila P Smirnova
Mar 7, 2020·Cell Metabolism·Fabien DucrocqPierre Trifilieff

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