Fatty acid composition in plasma and platelet phospholipid in hypothyroid patients before and after 1-thyroxine substitution

Scandinavian Journal of Clinical and Laboratory Investigation
S Valdemarsson, A Gustafson


The relative concentration of fatty acids in plasma and platelet phospholipids (phosphatidylcholine) was determined in 11 patients with overt hypothyroidism (S-TSH greater than 80 mU/l) before and after 1-thyroxine substitution therapy. During therapy, the linoleic (C18:2) acid content decreased (p less than 0.01) whereas longer and more desaturated fatty acids, including arachidonic (C20:4) acid, increased (p less than 0.01) in plasma phospholipids. Also, oleic (C18:1) acid decreased (p less than 0.01) while the major saturated fatty acids, palmitic (C16:0) and stearic (C18:0) acids, were stable. In platelet membrane phospholipids, a similar reciprocal change in the relative content of linoleic (C18:2) and arachidonic (C20:4) acids, respectively, occurred. In plasma, these changes in linoleic and arachidonic acids were found to be inversely correlated (r = 0.56, p less than 0.05). The change in the linoleic acid content in plasma was also correlated to that in platelets (r = 0.64, p less than 0.05). Thus, we have found that thyroid hormones positively influence the conversion of linoleic acid to longer and more polyunsaturated fatty acids in a way that affects fatty acid composition not only in plasma but also in platelet memb...Continue Reading


Apr 1, 1978·Scandinavian Journal of Clinical and Laboratory Investigation·B DanielssonJ Wadstein
Mar 1, 1975·Annals of Internal Medicine·J R EdsonR P Doe
Oct 28, 1967·British Medical Journal·N B BennettG M McAndrew
Dec 1, 1968·Scandinavian Journal of Clinical and Laboratory Investigation·A Nordöy, S Lund
Feb 1, 1969·Clinica Chimica Acta; International Journal of Clinical Chemistry·V Felt, P Husek
Nov 11, 1965·The New England Journal of Medicine·J V SimoneI Schulman


Apr 1, 1990·Scandinavian Journal of Clinical and Laboratory Investigation·H LarssonP Hedner

Related Concepts

Blood Platelets
Plasma Membrane
Saturated Fat

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Archaeal RNA Polymerase

Archaeal RNA polymerases are most similar to eukaryotic RNA polymerase II but require the support of only two archaeal general transcription factors, TBP (TATA-box binding protein) and TFB (archaeal homologue of the eukaryotic general transcription factor TFIIB) to initiate basal transcription. Here is the latest research on archaeal RNA polymerases.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.