Fatty acid composition in plasma and platelet phospholipid in hypothyroid patients before and after 1-thyroxine substitution

Scandinavian Journal of Clinical and Laboratory Investigation
S Valdemarsson, A Gustafson

Abstract

The relative concentration of fatty acids in plasma and platelet phospholipids (phosphatidylcholine) was determined in 11 patients with overt hypothyroidism (S-TSH greater than 80 mU/l) before and after 1-thyroxine substitution therapy. During therapy, the linoleic (C18:2) acid content decreased (p less than 0.01) whereas longer and more desaturated fatty acids, including arachidonic (C20:4) acid, increased (p less than 0.01) in plasma phospholipids. Also, oleic (C18:1) acid decreased (p less than 0.01) while the major saturated fatty acids, palmitic (C16:0) and stearic (C18:0) acids, were stable. In platelet membrane phospholipids, a similar reciprocal change in the relative content of linoleic (C18:2) and arachidonic (C20:4) acids, respectively, occurred. In plasma, these changes in linoleic and arachidonic acids were found to be inversely correlated (r = 0.56, p less than 0.05). The change in the linoleic acid content in plasma was also correlated to that in platelets (r = 0.64, p less than 0.05). Thus, we have found that thyroid hormones positively influence the conversion of linoleic acid to longer and more polyunsaturated fatty acids in a way that affects fatty acid composition not only in plasma but also in platelet memb...Continue Reading

References

Apr 1, 1978·Scandinavian Journal of Clinical and Laboratory Investigation·B DanielssonJ Wadstein
Mar 1, 1975·Annals of Internal Medicine·J R EdsonR P Doe
Oct 28, 1967·British Medical Journal·N B BennettG M McAndrew
Dec 1, 1968·Scandinavian Journal of Clinical and Laboratory Investigation·A Nordöy, S Lund
Feb 1, 1969·Clinica Chimica Acta; International Journal of Clinical Chemistry·V Felt, P Husek
Nov 11, 1965·The New England Journal of Medicine·J V SimoneI Schulman

Citations

Apr 1, 1990·Scandinavian Journal of Clinical and Laboratory Investigation·H LarssonP Hedner

Related Concepts

Blood Platelets
Plasma Membrane
Saturated Fat
Hypothyroidism
Phosphatidylcholines
Levoxyl

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