Fatty acid composition of adipose tissue, an indication of dietary fatty acids, and breast cancer prognosis

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
J A PetrekJ Hirsch

Abstract

Fatty acid composition of adipose tissue is an indicator of the long-term ingestion pattern of several specific fatty acids. There is good correlation of antecedent diet with the essential fatty acids, and there is reflection of the diet with the fatty acids that can be synthesized. The relationship between the fatty acid levels and lymph node status and clinical outcome was examined. At the time of diagnostic surgery, 161 women with clinical stage T1NO breast cancer had subcutaneous adipose tissue (breast and abdominal) aspirated. The concentrations of 35 fatty acids, seven summed classes, and six fatty acid groups were measured by capillary gas chromatography. Lymph node status was determined with axillary dissection, and patients were followed-up (mean, 7.3 years) for clinical outcome. There was no significant association of any adipose tissue fatty acids with overall survival, although few (16 of 161 women) died of breast cancer. However, the odds of having positive lymph nodes (57 of 161 women) were significantly higher for women with a greater adipose tissue proportion of oleic acid (odds ratio [OR], 7.56; 95% confidence interval [CI], 1.78 to 32.1) or total saturated acids (OR, 8.43; 95% CI, 1.48 to 40.0) and significant...Continue Reading

Citations

Jun 10, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ivan E DimitrovCraig R Malloy
Nov 15, 2015·Advances in Nutrition·Stephan J Guyenet, Susan E Carlson
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May 16, 2014·International Journal of Oncology·Catherine MounierEric Rassart
Jul 7, 2007·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Ewa PrzybytkowskiMarc Prentki
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