PMID: 3745880Jan 1, 1986Paper

Fatty acid composition of adipose tissue in patients with chronic liver disease

Journal of Hepatology
M MerliL Capocaccia

Abstract

In this study plasma free fatty acids and adipose tissue fatty acid composition in 10 cirrhotic patients, 5 patients with non-cirrhotic chronic liver disease and in 5 controls have been investigated. Fatty acid composition of adipose tissue in cirrhotic patients demonstrated a significant increase of 16:1 and a decrease of 18:2. Monounsaturated fatty acids represented the major fraction both in cirrhotic patients (57.5%) and in controls (55.2%). Polyunsaturated fatty acids were significantly lower in cirrhotic patients (9.1%) than in controls (14.3%). In plasma, total free fatty acids were higher in cirrhotics (732 +/- 111 microM) than in controls (319 +/- 38 microM; mean +/- SE) and the individual fatty acid profile showed a prevalence of monounsaturated fatty acid (increase of 16:1 and 18:1 and decrease of 16:0 and 18:0). The decrease in polyunsaturated fatty acids in the composition of adipose tissue triglycerides could represent a marker of long-term reduction in lipid absorption, intake and/or enhanced lipid consumption. The resemblance between plasma and adipose tissue pattern in cirrhotic patients supports the hypothesis that increased lipolysis in such patients plays the most important role in influencing plasma free fa...Continue Reading

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Citations

Apr 1, 1997·Journal of Gastroenterology and Hepatology·S T Fan
Sep 25, 2004·Mass Spectrometry Reviews·Kurt VarmuzaRobert M Mader
Jun 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F NozuT Tanaka
Nov 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·E Cabré, M A Gassull
Dec 10, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·E Cabré, M A Gassull
Jan 11, 2001·Current Opinion in Clinical Nutrition and Metabolic Care·E Cabré, M A Gassull

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