Fatty acid composition of liver, adipose tissue, spleen, and heart of mice fed diets containing t10, c12-, and c9, t11-conjugated linoleic acid

Prostaglandins, Leukotrienes, and Essential Fatty Acids
Darshan S KelleyBruce E Mackey

Abstract

Conjugated linoleic acid (CLA) isomers have unique effects on tissue lipids. Here we investigated the influence of individual CLA isomers on the lipid weight and fatty acid composition of lipid metabolizing (i.e. liver and retroperitoneal adipose) and lipid sensitive (i.e. spleen and heart) tissues. Female mice (8 week old; n=6/group) were fed either a control or one of the two CLA isomer supplemented (0.5%) diets for 8 weeks. The cis-9, trans-11-CLA diet reduced the 18:1n-9 wt% by 20-50% in liver, adipose tissue, and spleen, reduced the spleen n-3 polyunsaturated fatty acid (PUFA) by 90%, and increased the n-6 PUFA wt% by 20-50% in all tissues except heart. The trans-10, cis-12-CLA reduced both the n-6 and n-3 PUFA wt% in liver (>50%), reduced the heart n-3 PUFA wt% by 25%, and increased the wt% of spleen n-3 PUFA by 700%. The functional consequences of such changes in tissue fatty acid composition need to be investigated.

References

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Citations

Aug 20, 2008·The British Journal of Nutrition·Darshan S KelleyBruce E Mackey
Oct 25, 2008·The British Journal of Nutrition·Daichi OikawaMitsuhiro Furuse
Mar 1, 2012·The Proceedings of the Nutrition Society·Darshan S Kelley, Yuriko Adkins
Mar 5, 2011·Journal of Medicinal Food·Carina P Van NieuwenhoveSilvia N González
Feb 2, 2012·Journal of Nutritional Science and Vitaminology·Kenta SatoIkuo Ikeda
Jul 23, 2009·Nutritional Neuroscience·Shoichiro TsuyamaMitsuhiro Furuse
Feb 24, 2015·The British Journal of Nutrition·Tatiana M MarquesCatherine Stanton
Dec 3, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Christian-Alexandre CastellanoJ Jacques Matte
Mar 30, 2017·Revista da Associação Médica Brasileira·Phablo AbreuSandro Massao Hirabara
Jun 11, 2015·Journal of Lipid Research·Tejia ZhangAlan Saghatelian
Mar 15, 2015·Journal of Leukocyte Biology·Xiaofeng Wang, Marianna Kulka
Nov 22, 2007·The Journal of Nutrition·Nirvair S KelleyKent L Erickson
Nov 28, 2017·The British Journal of Nutrition·Jimena LavanderaClaudio A Bernal

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