PMID: 8947319Nov 1, 1996Paper

Fatty acid composition of liver total lipids in alcoholic patients with and without liver damage

Alcoholism, Clinical and Experimental Research
M P De La MazaD Bunout

Abstract

Alcohol ingestion may promote lipid peroxidation, and the presence of polyunsaturated fatty acids in liver lipids may be essential for the generation of liver damage through this mechanism. The aim of this study is to examine fatty acid composition of liver lipids in chronic alcoholics with and without histological liver damage. A percutaneous liver biopsy was performed to 28 patients hospitalized for treatment of their alcoholism. Liver total lipids were extracted from a portion of the tissue sample and fatty acid composition was measured by gas chromatography. Another piece of the sample was sent for histological study. Six patients had histological cirrhosis or alcoholic hepatitis in their biopsies, the rest of the patients had minimal changes. Patients with liver damage had higher levels of oleic acid and total monoenoic fatty acids, a higher 18:1/18:0 ratio, lower levels of polyunsaturated fatty acids, a lower 20:4/18:2 ratio, and a lower peroxidability index in liver total lipids, than patients without liver damage. Alcoholic patients with asymptomatic liver damage have less unsaturated fatty acids in liver total lipids than their counterparts with normal livers.

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Citations

Oct 2, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E Mezey
Dec 17, 2009·Topics in Magnetic Resonance Imaging : TMRI·William H PermanIsin Akduman
Dec 15, 2011·Lipids in Health and Disease·Xin WangXiuying Zhang
Aug 14, 2015·BMC Veterinary Research·Megumi FujiwaraToshiro Arai
Jun 27, 2014·The American Journal of Clinical Nutrition·Stefano Ginanni CorradiniLuigi Iuliano
Mar 23, 2011·Journal of Agricultural and Food Chemistry·Timothy W SirkEugene F Brown
Aug 5, 2008·Journal of Agricultural and Food Chemistry·Timothy W SirkMendel Friedman

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