Fatty acid composition of serum glycerophospholipids in children

The Journal of Pediatrics
Claudia GlaserB Koletzko

Abstract

To determine reference values for fatty acid (FA) composition of serum glycerophospholipids (GPs) in children with a new high-throughput method. The GP FA composition of 1326 serum samples obtained from a cohort of 951 children at 2 and 6 years, participating in the German Influences of Lifestyle Related Factors on the Immune System and the Development of Allergies in Childhood (LISA) study, was analyzed with a new high-throughput method. Only 2 simple preparation steps were necessary to obtain fatty acid methyl esters selectively from serum GPs. The FA status was determined by separating and quantifying the fatty acid methyl esters with high-resolution capillary gas chromatography. FA values in serum GPs were in very good agreement with other published values in serum or plasma phospholipids for most of the analyzed FAs. No major age and sex differences in GP FA composition were observed. The serum GP FA values obtained from children aged 2 and 6 years may serve as reference values in clinical practice (eg, for monitoring and improving therapeutic interventions). Furthermore, they can serve as a reference point for interpreting FA values in clinical and epidemiological studies.

References

Jul 1, 1994·European Journal of Pediatrics·T Decsi, B Koletzko
May 24, 2000·European Journal of Clinical Nutrition·A Zeleniuch-JacquotteP Toniolo
Dec 16, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·X C JiangA R Tall
Jul 30, 2002·The American Journal of Clinical Nutrition·Joanne CallowKeith N Frayn
Oct 3, 2002·The European Respiratory Journal·J HeinrichUNKNOWN LISA Study Group
Jul 23, 2005·Scandinavian Journal of Gastroenterology·Piotr SochaJerzy Socha
Jul 29, 2005·Critical Reviews in Food Science and Nutrition·M Fleith, M T Clandinin
Jan 13, 2006·Current Opinion in Lipidology·Ana Baylin, Hannia Campos
Mar 15, 2006·Molecular Genetics and Metabolism·H VlaardingerbroekM E Rubio-Gozalbo
Apr 19, 2006·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Stefanie SausenthalerUNKNOWN LISA Study Group
Jul 18, 2006·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·B Koletzko, T Decsi
Apr 3, 2007·The Journal of Allergy and Clinical Immunology·Chih-Mei ChenUNKNOWN LISA Study Group
Jun 26, 2007·Prostaglandins, Leukotrienes, and Essential Fatty Acids·P RiséC Galli
Nov 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·Avshalom CaspiTerrie E Moffitt
Nov 21, 2007·Annals of Nutrition & Metabolism·António GuerraBerthold Koletzko
Jan 11, 2008·Journal of Perinatal Medicine·Berthold KoletzkoUNKNOWN World Association of Perinatal Medicine Dietary Guidelines Working Group
Apr 26, 2008·Progress in Lipid Research·Leanne HodsonBarbara A Fielding
Apr 26, 2008·European Journal of Pediatrics·Viktória JakobikTamás Decsi
May 28, 2008·Molecular Nutrition & Food Research·Philip C Calder
Oct 29, 2008·Journal of Pediatric Gastroenterology and Nutrition·Asim MaqboolVirginia A Stallings
Aug 6, 2009·Journal of Lipid Research·Claudia GlaserBerthold Koletzko
Sep 25, 2009·Journal of Nutrigenetics and Nutrigenomics·Eva LattkaBerthold Koletzko
Jan 5, 2010·Metabolism: Clinical and Experimental·Claudia GlaserBerthold Koletzko

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Citations

May 25, 2012·The British Journal of Nutrition·Mario Klingler, Berthold Koletzko
Jun 28, 2012·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·J HeinrichS Koletzko
Jan 15, 2014·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Manja FleddermannBerthold Koletzko
Oct 4, 2016·International Journal of Food Sciences and Nutrition·Valeria DeonOrnella Guardamagna
Jan 21, 2017·International Journal of Molecular Sciences·Sławomira Drzymała-CzyżJarosław Walkowiak
Sep 16, 2014·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M WoltersW Ahrens

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