Fatty acid composition of the major phospholipids of Pneumocystic carinii: comparison with those in the lungs of normal and methylprednisolone-immunosuppressed rats.

Infection and Immunity
Z GuoE S Kaneshiro

Abstract

Large numbers of viable organisms can be isolated from the corticosteroid-immunosuppressed rat model of Pneumocystis carinii pneumonia. With the development of purification protocols that provide organism preparations of high purity, meaningful lipid biochemical analyses of this important opportunistic pathogen can now be conducted. The phospholipid class composition of the pathogen was reported earlier, together with observations of changes that occur in the rat lungs in response to methylprednisolone immunosuppression treatment. In this report, analyses of the effects of corticosteroids on the fatty acid compositions of the major lung phospholipids, individually isolated and purified by thin-layer chromatography, were elucidated and quantified by gas-liquid chromatography. In response to methylprednisolone, there was a relative increase in palmitate and there were decreases in several unsaturated fatty acids of the rat whole-lung total polar lipids leading to a doubling of the saturation index. Reciprocal changes in the relative concentrations of palmitate and stearate in phosphatidylethanolamine, phosphatidylinositol, lysophosphatidylcholine, and cardiolipin were observed, suggesting that there is tight control of acylation ...Continue Reading

References

Jan 1, 1987·Progress in Lipid Research·J L Harwood
Nov 1, 1994·The Journal of Eukaryotic Microbiology·J R Paulsrud, S F Queener
Nov 1, 1994·Antimicrobial Agents and Chemotherapy·S T FurlongJ A Fishman
Nov 1, 1993·The Journal of Eukaryotic Microbiology·E S KaneshiroS G Langreth
Jul 1, 1993·Journal of Clinical Microbiology·J R PaulsrudJ W Smith
Nov 1, 1995·The Journal of Eukaryotic Microbiology·M Florin-ChristensenE S Kaneshiro
Aug 1, 1959·Canadian Journal of Biochemistry and Physiology·E G BLIGH, W J DYER

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Citations

Jan 29, 2000·The Journal of Eukaryotic Microbiology·C BiderreC P Vivares
Jun 28, 2001·The Journal of Parasitology·H El AlaouiC P Vivarès
Oct 29, 1998·FEMS Immunology and Medical Microbiology·E S Kaneshiro
Mar 21, 1998·International Journal for Parasitology·E S Kaneshiro
Feb 11, 1998·Clinical Microbiology Reviews·E S Kaneshiro

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