Fatty Acid desaturase gene variants, cardiovascular risk factors, and myocardial infarction in the costa rica study.

Frontiers in Genetics
S AslibekyanAna Baylin

Abstract

Genetic variation in fatty acid desaturases (FADS) has previously been linked to long-chain polyunsaturated fatty acids (PUFAs) in adipose tissue and cardiovascular risk. The goal of our study was to test associations between six common FADS polymorphisms (rs174556, rs3834458, rs174570, rs2524299, rs174589, rs174627), intermediate cardiovascular risk factors, and non-fatal myocardial infarction (MI) in a matched population based case-control study of Costa Rican adults (n = 1756). Generalized linear models and multiple conditional logistic regression models were used to assess the associations of interest. Analyses involving intermediate cardiovascular risk factors and MI were also conducted in two replication cohorts, The Nurses' Health Study (n = 1200) and The Health Professionals Follow-Up Study (n = 1295). In the Costa Rica Study, genetic variation in the FADS cluster was associated with a robust linear decrease in adipose gamma-linolenic, arachidonic, and eicosapentaenoic fatty acids, and significant or borderline significant increases in the eicosadienoic, eicosatrienoic, and dihomo-gamma-linolenic fatty acids. However, the associations with adipose tissue fatty acids did not translate into changes in inflammatory biomark...Continue Reading

Citations

Jul 1, 2014·Current Nutrition Reports·Rasika A MathiasFloyd H Chilton
Jul 23, 2013·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Kaitlin RokeDavid M Mutch
Nov 27, 2015·Journal of Lipid Research·Maija VaittinenJussi Pihlajamäki
Aug 8, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Shannon L KlingelDavid M Mutch
Jun 26, 2020·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Wided KhamlaouiMohamed Hammami

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Methods Mentioned

BETA
blood draw
genotyping
oligonucleotide
enzymatic purification
PCR
electrophoresis

Software Mentioned

SAS
GeneMapper Analysis
MACH
ChemStation

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