Fatty Acid Diets: Regulation of Gut Microbiota Composition and Obesity and Its Related Metabolic Dysbiosis.

International Journal of Molecular Sciences
David Johane MachateArnildo Pott

Abstract

Long-term high-fat dietary intake plays a crucial role in the composition of gut microbiota in animal models and human subjects, which affect directly short-chain fatty acid (SCFA) production and host health. This review aims to highlight the interplay of fatty acid (FA) intake and gut microbiota composition and its interaction with hosts in health promotion and obesity prevention and its related metabolic dysbiosis. The abundance of the Bacteroidetes/Firmicutes ratio, as Actinobacteria and Proteobacteria species are associated with increased SCFA production, reported high-fat diet rich in medium-chain fatty acids (MCFAs), monounsaturated fatty acids (MUFAs), and n-3 polyunsaturated fatty acids (PUFAs) as well as low-fat diets rich in long-chain fatty acids (LCFAs). SCFAs play a key role in health promotion and prevention and, reduction and reversion of metabolic syndromes in the host. Furthermore, in this review, we discussed the type of fatty acids and their amount, including the administration time and their interplay with gut microbiota and its results about health or several metabolic dysbioses undergone by hosts.

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Citations

Jan 21, 2021·International Journal of Molecular Sciences·Xiaofei WangHao Zheng
Feb 9, 2021·Frontiers in Nutrition·Carlos O Mendivil
Mar 12, 2021·Advances in Nutrition·Kirsten BerdingJohn F Cryan
Jun 18, 2021·Critical Reviews in Food Science and Nutrition·Sherif ShaheenMohamed A Farag
Nov 5, 2021·Journal of Proteome Research·Belén Callejón-LeblicTamara García-Barrera

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