PMID: 3758459Jan 1, 1986Paper

Fatty acid induced hemolysis. Protective action of ceruloplasmin, albumins, thiols and vitamin C

The International Journal of Biochemistry
R A Løvstad

Abstract

The hemolytic effect of saturated fatty acids increased rapidly, when the number of carbon atoms in the chain exceeded 12. At low fatty acid concentrations (less than 60 microM) the hemolytic effect decreased with increasing number of double bonds in the carbon chain (cis-form fatty acids). A more complex pattern was observed at higher fatty acid concentrations. Trans-unsaturated fatty acids were more hemolytic than cis-analogs. Ceruloplasmin, a serum protein with no fatty acid binding capacity, reduced the hemolytic effect of fatty acids; possibly by interacting with the cell membrane. Reducing compounds (thiols, vitamin C) also protected against fatty acid induced hemolysis.

References

Oct 1, 1979·Agents and Actions·C W Denko
Nov 15, 1977·The Biochemical Journal·D J Al-Timimi, T L Dormandy
Jul 11, 1977·Biochemical and Biophysical Research Communications·J M Gutteridge
Nov 30, 1984·Biochemical and Biophysical Research Communications·G Barnes, E Frieden
Jan 1, 1983·The International Journal of Biochemistry·R A Løvstad
Jan 1, 1981·Critical Reviews in Clinical Laboratory Sciences·J M Gutteridge, J Stocks
Jan 1, 1982·The International Journal of Biochemistry·R A Løvstad
Sep 1, 1981·The Journal of Clinical Investigation·A C Chou, C D Fitch
Apr 1, 1962·The Journal of Clinical Investigation·H S JACOB, J H JANDL
Mar 1, 1982·Biological Trace Element Research·F J CarverE Frieden

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Citations

Jan 1, 1991·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·M R KasschauM P Byam-Smith
Dec 1, 1991·Transfusion Medicine·S R LangtonM Hellings
May 1, 1991·American Journal of Respiratory Cell and Molecular Biology·P G DuaneD E Niewoehner
Jan 23, 2013·International Journal of Pharmaceutics·Xiaona LiuXiangqun Jin
Oct 26, 2016·Chemistry and Physics of Lipids·Ahmad ArouriOle G Mouritsen
Oct 20, 1988·Biochimica Et Biophysica Acta·A KozubekA F Sikorski

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