Fatty acid interdigitation in stratum corneum model membranes: a neutron diffraction study.

European Biophysics Journal : EBJ
A RuettingerR H H Neubert

Abstract

The influence of the chain length of the free fatty acid (FFA) in a stratum corneum (SC) lipid model membrane composed of N-(alpha-hydroxyoctadecanoyl)-phytosphingosine (CER [AP]), cholesterol (Ch), FFA and cholesterol sulphate (ChS) was investigated by neutron diffraction. The internal nanostructure of the SC lipid membrane in addition to the water distribution function was determined via calculation of the neutron scattering length density profile (Fourier profile). The Fourier profiles of the studied SC model membranes revealed that such membranes have a repeat distance approximately equal to the membrane thickness. Increasing the chain length of the FFA in the CER[AP] based model membrane did not cause an alteration of the internal nanostructure but led to a decrease in the membrane repeat distance from 45.6 angstroms (palmitic acid, C16:0) to 43.7 angstroms (cerotic acid, C26:0) due to a partial interdigitation of the FFA chains. Ceramide [AP] forces the long chain fatty acids to incorporate into the unchanged spacing of the bilayer, thereby obligating the FFA protrude partly through opposing leaflet. Furthermore, the longer chained free fatty acids tend to form a new separate so-called "fatty acid rich phase". Therefore, ...Continue Reading

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Citations

Jan 25, 2008·European Biophysics Journal : EBJ·Doreen KessnerReinhard H H Neubert
Apr 23, 2008·European Biophysics Journal : EBJ·Doreen KessnerReinhard H H Neubert
Dec 17, 2009·European Biophysics Journal : EBJ·Natalia Yu RyabovaA M Balagurov
Dec 17, 2014·The Journal of Chemical Physics·Christopher M MacDermaidGiacomo Fiorin
Mar 16, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·M OchalekR H H Neubert
Nov 7, 2015·Neurochemical Research·Sara GrassiAlessandro Prinetti
Oct 14, 2008·Biochimica Et Biophysica Acta·Félix M Goñi, Alicia Alonso
Sep 29, 2011·Chemistry and Physics of Lipids·Laura CantùAlessandro Prinetti
Jun 4, 2015·Biophysical Journal·Enamul H MojumdarJoke A Bouwstra
Mar 4, 2017·Biointerphases·Vytis ČižinauskasVitalis Briedis
Jun 26, 2020·Journal of Molecular Modeling·Yogesh BadheBeena Rai
Jan 5, 2021·Chemical & Pharmaceutical Bulletin·Hiroki OhnariYasuko Obata
Aug 19, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Sören StahlbergDaniel Huster
Oct 7, 2008·Biochimica Et Biophysica Acta·Alessandro PrinettiSandro Sonnino

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