PMID: 6413804Aug 1, 1983Paper

Fatty acid metabolism and cell proliferation: IV. Effect of prostanoid biosynthesis from endogenous fatty acid release with cyclosporin-A

Lipids
J A LindseyD G Cornwell

Abstract

Cyclosporin-A (Cyc-A) stimulates prostanoid (PGI2) synthesis in confluent smooth muscle cells from guinea pig aorta through the release of endogenous fatty acid. Cyc-A, like other stimulatory agents for prostanoids, promotes smooth muscle cell proliferation and prostanoid synthesis in these proliferating cells. Indomethacin, a cyclooxygenase inhibitor, and exogenous arachidonic acid block the Cyc-A effect on cell proliferation.

References

Jan 1, 1980·Journal of Supramolecular Structure·M G Goodman, W O Weigle

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Citations

Jul 27, 2000·Journal of Cellular Physiology·T E PhillipsC P Moore
Sep 1, 1990·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J Mason
Sep 1, 1989·Klinische Wochenschrift·W H HörlH Wilms
Jan 1, 1986·International Journal of Immunopharmacology·O H NielsenJ Elmgreen
Jan 1, 1997·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·B Wondimu, T Modéer
Feb 1, 1989·Kidney International·D C LauW S Hwang
Jan 1, 1989·Renal Failure·L J BrunnerD R Luke

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