Fatty Acid Metabolism in Immune Cells: A Bioinformatics Analysis of Genes Involved in Ulcerative Colitis

DNA and Cell Biology
Meiao TanKeer Huang

Abstract

Many immune cells participate in the pathogenesis of ulcerative colitis (UC), and fatty acid metabolism (FAM) is reported to supporting their cell-specific functions and proliferation, but the underlying mechanism is unclear. This study aimed to investigate the relationship between FAM and inflammation in colon tissues and identify potential therapeutic targets for regulating immune response. A total of 870 different expression genes (DEGs), 304 immunity-related DEGs, and 11 FAM-related DEGs were obtained, gene ontology analysis results showed that immune DEGs were significantly enriched in neutrophil migration, positive regulation of T cell activation. Fifteen types of immune cells were identified in inflamed colon tissues. Five FAM-related DEGs (ACOX1, ACSL4, ELOVL5, FADS2, and SCD) were highly correlated with immunity-related DEGs, and ACSL4, ELOVL5, and FADS2 were significantly upregulated in immune cells, while SCD is downregulated. Five FAM-related DEGs were highly correlated with immune cells. The study promotes the understanding of the pathogenesis of FAM in UC immune cells.

References

Aug 6, 2000·Yeast·J Wixon, D Kell
May 7, 2002·Scandinavian Journal of Gastroenterology·H LührsT Menzel
Jan 8, 2008·Cell Metabolism·Ralph J DeBerardinisCraig B Thompson
Jul 1, 2009·European Journal of Clinical Investigation·A KoppA Schäffler
Sep 3, 2010·Cell Biochemistry and Biophysics·Thais Martins de Lima-SalgadoRui Curi
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Jenny E KanterKarin E Bornfeldt
Mar 8, 2014·Acta Dermato-venereologica·Ryuhei UchiyamaRyuhei Okuyama
Sep 10, 2014·Mayo Clinic Proceedings·Joseph D Feuerstein, Adam S Cheifetz
Jan 17, 2015·Trends in Immunology·Matthias LochnerTim Sparwasser
Jun 16, 2015·World Journal of Gastroenterology : WJG·Jun YaoLi-Sheng Wang
Feb 26, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ashwin N AnanthakrishnanIsaac Kohane
Mar 2, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Su-Min LimDong-Hyun Kim
May 24, 2016·European Journal of Immunology·Kristin StelznerAnja Saalbach
Mar 1, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Seon-Yeong LeeMi-La Cho
Dec 19, 2017·The British Journal of Nutrition·Yang-Yi FanRobert S Chapkin
Jan 19, 2018·Methods in Molecular Biology·Binbin ChenAsh A Alizadeh
Sep 4, 2018·Scandinavian Journal of Immunology·Xuchen QianErzhen Chen
Oct 8, 2018·Journal of Lipid Research·Philippe-Pierre RobichaudMarc E Surette
Jan 21, 2020·Drug Discoveries & Therapeutics·Yutaro MotoiTakahiro Kubota

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Citations

May 28, 2021·The Kaohsiung Journal of Medical Sciences·Li-Hong HuJi-Bin Yin

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Datasets Mentioned

BETA
GSE75214
GSE87466

Methods Mentioned

BETA
Single Cell Sequencing
metabolomic profiling

Software Mentioned

Bioconductor
DAVID
R
CIBERSORT
ClueGO
R language code
Cytoscape

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