PMID: 1201765Nov 21, 1975Paper

Fatty acid pattern of lipids in normal and dystrophic human muscle

European Journal of Clinical Investigation
D KunzeK Döhler

Abstract

The fatty acid distribution of the main lipid fractions: triglycerides (TG), phosphatidylcholine (PCh), phosphatidylethanolamine (PE), and sphingomyelin (Sph) of muscle from 6 patients with progressive muscular dystrophy (p.m.d.), Duchenne, 8 to 12 years old was estimated and compared with normal controls of different age. In view of the results of several authors about varied fatty acid distribution in immature muscle a third group comprising samples of neonatal muscle was studied. 1. The fatty acid pattern of the lipid fractions TG, Sph, and PE from muscle of patients with p.m.d. shows no important variation in comparison to normal controls. In contrast to this the fatty acid distribution in PCh is extremely varied: the percentage of 18:2 is decreased and corrrespondingly the content of 18:1 is increased. In view of the high percentage (nearly 10%) in which linoleic acid is substituted by oleic acid in PCh, effects on the plasma membrane are to be expected. 2. The fatty acid pattern in neonatal muscle shows in narly all positions of the fractions TG, Sph, PE, and PCh a different distribution from normal or dystrophic muscle. In view of the most important variation in dystrophic muscle it must be stated that generally 18:2 is ...Continue Reading

References

Aug 1, 1970·Clinica Chimica Acta; International Journal of Clinical Chemistry·T O Kleine
Feb 1, 1972·Clinica Chimica Acta; International Journal of Clinical Chemistry·D Kunze, D Olthoff
Oct 1, 1972·Journal of Neurology, Neurosurgery, and Psychiatry·B P Hughes
Sep 1, 1971·Biochimica Et Biophysica Acta·A Bruce, L Svennerholm
Jul 1, 1971·Clinica Chimica Acta; International Journal of Clinical Chemistry·D KunzeG Bönsch
Sep 1, 1970·Clinica Chimica Acta; International Journal of Clinical Chemistry·D Kunze, D Olthoff
Apr 1, 1968·Clinica Chimica Acta; International Journal of Clinical Chemistry·A TakagiK Nakao
Apr 29, 1969·Biochimica Et Biophysica Acta·L M van GoldeL L van Deenen

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Citations

May 1, 1981·Journal of the Neurological Sciences·V IonasescuL Z Stern
Feb 15, 2014·The British Journal of Nutrition·Gregory C HendersonMarc A Tuazon
Nov 21, 2007·Journal of Lipid Research·Nora TahallahOlivier Laprévote
Jul 28, 2009·Neurobiology of Disease·Farida BenabdellahSabine De La Porte
Apr 28, 2004·Experimental Physiology·Jørn Wulff HelgeJan Gorski
Nov 1, 1977·Biological Reviews of the Cambridge Philosophical Society·J A Witkowski
Jan 15, 2002·American Journal of Physiology. Endocrinology and Metabolism·Agnieszka Dobrzyń, Jan Górski

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