PMID: 698209Sep 11, 1978Paper

Fatty acid requirements and temperature dependence of monooxygenase activity in rat liver microsomes

Biochimica Et Biophysica Acta
J F BeckerJ C Bartholomew

Abstract

The effect of variation in the microsomal membrane fatty acid composition on Arrhenius plot phase transition temperatures for p-nitroanisole O-demethylation and benzo[a]pyrene hydroxylation has been investigated. In liver microsomes from normal-dieted rats, p-nitroanisole O-demethylase activity has a break temperature at 24 degrees C, while that of benzo[a]pyrene hydroxylase occurs at 29 degrees C indicating that these two enzymes may exist in different patches of membrane. The microsomal membrane fatty acid composition was altered by starving rats for 48 h and then refeeding them a fat-free diet for 4 or 5 days. In microsomes having diet-altered fatty acid compositions, benzo[a]pyrene hydroxylase has a break temperature at 33 degrees C, a value higher than that observed in normal-dieted rats. This observation correlates with the increase in saturation observed in the diet-altered fatty acid composition and thus may correspond to a phase transition roughly dependent on the fatty acid melting point. Induced and basal levels of cytochrome P-450 and P-448 in animals having different microsomal fatty acid composition are reported. Phenobarbital-induced levels of p-nitroanisole O-demethylase in normal microsomes were six times highe...Continue Reading

References

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Citations

Jan 1, 1990·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·H M CarpenterL R Curtis
Jan 1, 1981·Experimental Gerontology·L E Rikans, B A Notley
Jan 1, 1982·Experimental Gerontology·H J ArmbrechtB B Davis
May 15, 1990·Archives of Biochemistry and Biophysics·D W Seybert

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