Fatty acid synthase expression and its association with clinico-histopathological features in triple-negative breast cancer

Oncotarget
Ariadna Giró-PerafitaTeresa Puig Miquel

Abstract

Triple-Negative Breast Cancer (TNBC) has poor prognosis and no approved targeted therapy. We previously showed that the enzyme fatty acid synthase (FASN) was largely expressed in a small TNBC patients' cohort and its inhibition synergized with cetuximab in TNBC preclinical mouse models. Here, we evaluated FASN and EGFR expression in a cohort of TNBC patients and we study their prognostic role and their association with clinico-histopathological features, intrinsic TNBC subtypes and survival. FASN, EGFR, CK5/6 and vimentin expression were retrospective evaluated by Immunohistochemistry in 100 primary TNBC tumors. FASN expression was classified into high and low FASN groups. EGFR, CK5/6 and vimentin expression were used in TNBC intrinsic subtypes classification. FASN was expressed in most of the TNBC patients but did not correlate with overall survival or disease-free survival in this cohort. High FASN group was significantly associated with positive node status. FASN expression was significantly higher in Basal-Like patients than in Mesenchymal-Like ones. EGFR expression was positive in 50% of the tumors, and those patients showed poorer DFS. Altogether, our findings provide a rationale for further investigation the prognostic r...Continue Reading

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Citations

Mar 17, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ariadna Giró-PerafitaTeresa Puig
Apr 17, 2020·Frontiers in Oncology·Xiangyu SunYingying Xu
Oct 6, 2020·Frontiers in Nutrition·Ornella I SelminDonato F Romagnolo
May 13, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Joan Crous-MasóTeresa Puig
Nov 17, 2020·Frontiers in Oncology·Lara P FernándezAna Ramírez de Molina
May 1, 2021·Cancers·Mohamed Iman Hidayat Nor AziziRakesh Naidu
Aug 18, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sagar D SardesaiKathy D Miller

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Methods Mentioned

BETA
xenografts
light microscopy

Software Mentioned

SPSS
R

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