Fatty acid synthase (FAS) expression in human breast cancer cell culture supernatants and in breast cancer patients

Cancer Letters
Y WangDaniel W Chan

Abstract

Fatty acid synthase (FAS) is selectively expressed in certain human cancers, including carcinoma of the breast, prostate, colon, ovary, and endometrium, compared to normal human tissues and therefore is a putative tumor marker. In this study, we found FAS concentrations were elevated in cell culture supernatants during cell growth in two human breast cancer cell lines but not other cancer cell lines. A quantitative enzyme-linked immunosorbent assay and Western blot analysis were employed in this study. In addition, serum FAS levels were significantly higher in breast cancer patients with different clinical stages (Stage II: 0.59+/-0.09 units/l, Stage III: 0.79+/-0.13 units/l, and Stage IV: 1.39+/-0.35 units/l) compared with healthy subjects (0.27+/-0.02 units/l, P<0.05). Taken together, our data suggest that FAS expression may be a useful tumor marker for breast cancer and play a role in assessing cancer virulence.

References

Sep 7, 1989·The New England Journal of Medicine·F P KuhajdaG R Pasternack
Jul 20, 1982·Biochimica Et Biophysica Acta·B J Thompson, S Smith
Nov 13, 1981·Biochimica Et Biophysica Acta·B J ThompsonS Smith
Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·F P KuhajdaG R Pasternack
Jan 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·Y S ChoY S Cho-Chung
Feb 13, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·Y WangD W Chan

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Citations

Jul 6, 2011·Journal of Gastrointestinal Cancer·Maria NotarnicolaMaria Gabriella Caruso
Jan 31, 2004·Gynecologic Oncology·Valeria SebastianiPiero Luigi Alo
Jan 18, 2003·The International Journal of Biochemistry & Cell Biology·Fan WangHai-Meng Zhou
Sep 14, 2002·Journal of Immunoassay & Immunochemistry·Young Y WangDaniel W Chan
Dec 22, 2011·Nucleic Acids Research·Gillian H LittleBaruch Frenkel
Sep 22, 2005·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Piero L AloUgo D I Tondo
Sep 3, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kim WalterMichael Goggins
Nov 1, 2012·Lipids in Health and Disease·Maria NotarnicolaMaria Gabriella Caruso
Sep 5, 2009·Clinical Chemistry and Laboratory Medicine : CCLM·Judit MarsillachJordi Camps
Jun 11, 2008·Journal of Zhejiang University. Science. B·Wei-qin WangYun Liang
Jul 10, 2012·Indian Journal of Pathology & Microbiology·Zhi Li LiuYong Shu
Jan 17, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Qi-qiang LongPei-lin Huang
Dec 3, 2014·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Margrét BessadóttirHelga M Ogmundsdóttir
Mar 8, 2014·World Journal of Gastroenterology : WJG·Julian SwierczynskiTomasz Sledzinski
Mar 10, 2009·Medicina clínica·Teresa PuigRamon Colomer
Nov 27, 2008·Biochemical and Biophysical Research Communications·Cristina Oliveras-FerrarosJavier A Menendez
Oct 28, 2016·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Manjari SinghGaurav Kaithwas
Apr 12, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Masashi InafukuHirosuke Oku
Oct 3, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Wei YangTianyi Wang
Nov 1, 2007·Expert Opinion on Investigational Drugs·Steven J KridelCharles W Pemble
Jun 15, 2007·BMC Genomics·Lynn M Knowles, Jeffrey W Smith
Mar 20, 2010·Diabetes·Jose Manuel Fernandez-RealAntonio Vidal-Puig
Feb 4, 2010·Biochimica Et Biophysica Acta·Eiji FurutaKounosuke Watabe
Sep 12, 2006·Analytical Biochemistry·James KristieJames A Landro
Sep 16, 2005·Journal of Lipid Research·Yongsheng ChangRobert J Mason
May 4, 2018·Expert Opinion on Investigational Drugs·Alejandro Schcolnik-CabreraAlfonso Dueñas-González
Sep 19, 2017·Expert Opinion on Therapeutic Targets·Javier A Menendez, Ruth Lupu
May 23, 2018·Medicinal Research Reviews·Ma Carmen OcañaMiguel Ángel Medina
May 13, 2004·The Journal of Biological Chemistry·Lynn M KnowlesJeffrey W Smith
Dec 2, 2017·Electrophoresis·Roshanak AslebaghCostel C Darie
Apr 2, 2008·IUBMB Life·Wen-Hua ZhaoYing-Xia Zhang
Oct 27, 2010·Annals of the New York Academy of Sciences·G OliverasT Puig
Sep 14, 2006·British Journal of Cancer·W ZhaoM Robbins
Dec 30, 2006·Journal of Enzyme Inhibition and Medicinal Chemistry·Wen-Hua ZhaoWei-Xi Tian

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