Fatty Acid/Phospholipid Blended Membranes: A Potential Intermediate State in Protocellular Evolution

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Lin JinJack W Szostak

Abstract

Prior to the evolution of membrane proteins, intrinsic membrane stability and permeability to polar solutes are essential features of a primitive cell membrane. These features are difficult to achieve simultaneously in model protocells made of either pure fatty acid or phospholipid membranes, raising the intriguing question of how the transition from fatty acid to phospholipid membranes might have occurred while continuously supporting encapsulated reactions required for genomic replication. Here, the properties of a blended membrane system composed of both oleic acid (OA), a monoacyl fatty acid, and 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC), a diacyl phospholipid are described. This hybrid vesicle system exhibits high stability to divalent cations (Mg2+ ), while simultaneously maintaining its permeability to small charged molecules such as nucleotides and divalent ions such as Mg2+ . This combination of features facilitates key reactions expected to occur during a transition from primitive to modern cells, including nonenzymatic RNA replication, and is also compatible with highly evolved functions such as the ribosomal translation of a protein. The observations support the hypothesis that the early transition fro...Continue Reading

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Aug 6, 2019·Chembiochem : a European Journal of Chemical Biology·Hendrik R SikkemaBert Poolman
Jun 11, 2020·Molecular Biology and Evolution·Jesper S HansenCatharina Svanborg
Dec 5, 2018·Experimental Biology and Medicine·O Duhan Toparlak, Sheref S Mansy
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