Fatty acids inhibit adrenocorticotropin-induced adrenal steroidogenesis

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
L A Matthys, E P Widmaier

Abstract

Unsaturated long chain fatty acids modulate hormone secretion from a variety of endocrine glands, including the adrenal cortex. Oleic acid and linoleic acid have been shown to stimulate production of glucocorticoids in the absence of adrenocorticotropic hormone, but at a high concentration appeared to inhibit the action of this hormone. In the present study, the concentration dependence of the inhibitory actions of these two fatty acids was tested in collagenase-dispersed rat adrenal fasciculata cells, and the effects of both lipids on cAMP production were also determined. Adrenocorticotropic hormone stimulated steroid production from isolated cells approximately ten-fold above unstimulated cells. Oleic and linoleic acid significantly inhibited the response to this hormone by 44% and 54%, respectively. The half-maximally effective inhibitory concentration of both lipids was between 75-100 microM. A maximal concentration of adrenocorticotropic hormone increased cAMP secretion 138-fold above unstimulated cells. Oleic and linoleic acids inhibited the increase in cAMP secretion by 47% and 33%, respectively. It is concluded that pathophysiological concentrations of unsaturated fatty acids inhibit the action of adrenocorticotropic ho...Continue Reading

Citations

Mar 9, 2013·American Journal of Respiratory Cell and Molecular Biology·Qian WangSheng-Wei Jin
Sep 24, 2010·Developmental Psychobiology·Claire-Dominique Walker
Jul 15, 2006·Metabolism: Clinical and Experimental·Knut MaiAndreas F H Pfeiffer
Apr 20, 2007·Biology of Reproduction·D Claire WathesR John Aitken
Aug 10, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J T DourmashkinS F Leibowitz
Mar 11, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·H RaffT L Goodfriend

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