PMID: 8592868Nov 1, 1995Paper

Fatty acyl-CoA oxidase activity is induced before long-chain acyl-CoA hydrolase activity and acyl-CoA binding protein in liver of rat treated with peroxisome proliferating 3-thia fatty acids

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
J SkorveR K Berge

Abstract

1. In this study we explored the relationship between specific acyl-CoA esters and induction of acyl-CoA binding protein (ACBP) and enzymes related to the proliferation of peroxisomes. Male Wistar rats were administered a single dose (150 mg/day/kg) of sulphur-substituted fatty acid analogues, and the effects of tetradecylthioacetic acid and 3-thiadicarboxylic acid, which both act as peroxisome proliferators, were compared with the effects of tetradecylthiopropionic acid and palmitic acid which do not induce peroxisome proliferation. 2. The hepatic level of total long-chain acyl-CoA was significantly increased within 12 h of feeding these fatty acids, except in rat fed tetradecylthioacetic acid. Hplc chromatograms of liver extracts prepared from rat fed tetradecylthioacetic acid showed that tetradecylthioacetyl-CoA ester accumulated in the liver 4 h after feeding and had disappeared after 24 h. In liver extracts of the tetradecylthiopropionic acid-treated rat tetradecylthiopropionyl-CoA was not observed, but the appearance of a new long-chain acyl-CoA ester, probably a metabolite of tetradecylthiopropionic acid, was detected. This new peak reached a maximum 4h after feeding. In rat fed tetradecylthioacetic acid and 3-thiadicarb...Continue Reading

References

Apr 1, 1988·British Journal of Cancer·R AaslandK Kleppe
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·D DiMaioT Maniatis
Jun 9, 1993·Molecular and Cellular Biochemistry·J KnudsenK Kristiansen

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Citations

Jun 9, 1993·Molecular and Cellular Biochemistry·J KnudsenK Kristiansen
Sep 1, 1996·Lipids·R E GossettF Schroeder
Oct 24, 1998·The International Journal of Biochemistry & Cell Biology·M Marmunti, A Catalá
Jan 22, 2009·Médecine sciences : M/S·Erwan BeauchampPhilippe Legrand
Jun 5, 2002·Current Opinion in Lipidology·Rolf K BergeHans Grav
Aug 1, 1997·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·A GarrasR K Berge
Apr 23, 2015·Progress in Lipid Research·Ditte NeessNils J Færgeman

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