Fatty acyl desaturation in isolated hepatocytes from Atlantic salmon (Salmo salar): stimulation by dietary borage oil containing gamma-linolenic acid

Lipids
D R TocherJ R Sargent

Abstract

The effects of different dietary oils on the fatty acid compositions of liver phospholipids and the desaturation and elongation or [1-14C]18:3n-3 and [1-14C]18:2n-6 were investigated in isolated hepatocytes from Atlantic salmon. Atlantic salmon smolts were fed diets containing either a standard fish oil (FO) as a control diet, a 1:1 blend of Southern Hemisphere marine oil and tuna orbital oil (MO/TO), sunflower oil (SO), borage oil (BO), or olive oil (OO) for 12 wk. The SO and BO diets significantly increased the percentages of 18:2n-6, 18:3n-6, 20:2n-6, 20:3n-6, and total n-6 polyunsaturated fatty acids (PUFA) in salmon liver lipids in comparison with the FO diet. The BO diet also increased the percentage of 20:4n-6. Both the SO and BO diets significantly reduced the percentages of all n-3 PUFA in comparison with the FO diet. The OO diet significantly increased the percentages of 18:1n-3, 18:2n-6, total monoenes, and total n-6 PUFA in liver lipids compared to the FO diet, and the percentages of all n-3 PUFA were significantly reduced. With [1-14C]18:3n-3, the recovery of radioactivity in the products of delta 6 desaturation was significantly greater in the hepatocytes from salmon fed SO, BO, and OO in comparison with the FO di...Continue Reading

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Citations

Jun 1, 2005·Biochimica Et Biophysica Acta·Ingunn StubhaugBente E Torstensen
Dec 31, 2003·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Douglas R TocherPatrick J Campbell
Feb 9, 2000·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·S Varghese, O V Oommen
Feb 13, 2001·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·S VargheseO V Oommen
Apr 6, 2001·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·S LeenaO V Oommen
Sep 7, 2001·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·D R TocherJ R Dick
Jul 2, 2002·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Covadonga RodríguezR James Henderson
Feb 6, 2003·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Xavier RollinYvan Larondelle
Dec 18, 2008·Nutrition Research Reviews·Matthew R MillerChris G Carter
Jan 13, 2010·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Mercedes Díaz-LópezCovadonga Rodríguez
Jul 29, 2006·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·C Moya-FalcónB Ruyter
Mar 4, 2006·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Giovanni M TurchiniSena S De Silva

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