PMID: 2110958Feb 1, 1990Paper

Fatty change in the human temporomandibular joint disc. Light and electron microscopy study

International Journal of Oral and Maxillofacial Surgery
E S HelmyR A Bays

Abstract

Joint pain has been associated with fatty infiltration of the knee articulation. The purpose of this study is to report on the histopathological findings, especially fatty changes, that are seen in surgical specimens from the temporomandibular joints (TMJ) of patients that had persistent pain after non-surgical therapy. Forty plicated TMJ retrodiscal samples from 25 patients were used in this study. The patients were previously treated with splints for variable periods but not less than 2 months. The specimens were obtained by 2 surgeons using standard TMJ plication techniques. Control disc specimens were obtained from normal appearing cadaveric TM joints. Samples were immediately immersed in glutaraldehyde and processed for light and electron microscopic examination. The specimens were composed mainly of moderately dense tissue with cells that appeared fibroblastic and intermittent chondrocytic type cells. Fatty change, exclusively in association with the perivascular areas, was observed in 27 of 40 specimens. Electron microscopy showed fibroblasts, as well as large fat inclusions adjacent to elastin macroglobules. Fatty infiltration of the TMJ has been interpreted as a degenerative change. It is postulated that kinins and pro...Continue Reading

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Citations

Sep 1, 1994·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·A M Ali, M M Sharawy
Aug 27, 2010·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Carla LoretoRosalia Leonardi
Jun 12, 2013·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Flavio de Alcântara CamejoPaula Cristina Trevilatto
Dec 1, 1995·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·S B Milam, J P Schmitz
Jan 18, 2006·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Petra ThurmüllerLeonard B Kaban
Nov 13, 2007·The Journal of Craniofacial Surgery·Rosalia LeonardiLorenzo Lo Muzio
Jul 30, 1999·Cranio : the Journal of Craniomandibular Practice·O F Molina, J dos Santos Júnior

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