PMID: 5907913Jan 14, 1966

Fatty change of the granular pneumocyte

Science
E ValdiviaJ D'Amato

Abstract

Fat vacuoles develop in the granular pneumocytes of guinea pigs exposed to severe hypoxia in low-pressure chambers. The ostiniophilic lamellar bodies are apparently reduced in size and decreased in number. The fatty change of the granular pneumocyte may represent a metabolic alteration and interfere with the production of surfactant. This hypoxic lesion of the pneumocyte may be a significant factor in high-altitude pulmonary insufficiency.

Citations

Jul 23, 1970·The New England Journal of Medicine·D A Clark
Jan 1, 1971·Preparative Biochemistry·C H WilliamsE Valdivia
Nov 1, 1966·Australasian Radiology·H A VAN DEN BRENK
Nov 1, 1989·The American Review of Respiratory Disease·J D EdelsonR J Mason
Nov 22, 1976·Virchows Archiv. A, Pathological Anatomy and Histology·K G Eden, H B von Seebach
Aug 1, 1979·Chemico-biological Interactions·B W StewartA W Lykke
Jun 28, 1985·Toxicology·J P Kehrer, S Kacew
May 1, 1985·Toxicology·P G ForkertJ S Poland
Mar 31, 2004·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·M OchsJ Richter
Jun 1, 1968·Cancer·F Masin, M Masin
May 1, 1967·Clinical Pediatrics·H I LecksA I Sutnick

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