PMID: 16505760Mar 1, 2006Paper

Fatty infiltration of the liver. Detection and grading using dual T1 gradient echo sequences on clinical MR system

Gastroentérologie Clinique Et Biologique
Frank PilleulPierre-Jean Valette

Abstract

To evaluate the relationship between histopathology results and magnetic resonance imaging (MRI) on in and opposed-phase sequences grading of fat deposition within human liver. In and opposed-phase T1-weighted gradient-echo sequences (double echo time 2.3 ms and 4.6 ms) were performed in 25 patients, using a 1.5-T clinical MR imaging system. Fat/water ratio on in- and opposed-phase images of the liver was compared with pathologically defined degree of steatosis. The signal intensity in the images was acquired with operator-defined regions of interest at the same location in both fat and water images and the ratio was calculated by dividing signal intensity of liver in opposed phased sequence on signal intensity of liver in phased sequence. Fat/water ratio and the degree of steatosis were compared using linear regression. The sensitivity and specificity of opposed-phase for diagnosing steatosis were defined by ROC analysis. Furthermore, a correlation between visual signal intensity variation and the degree of steatosis was assessed using Pearson correlation coefficient. Histology demonstrated fatty liver infiltrations in 81% of specimens. The percentage of fatty hepatocytes was 28 +/- 30%. Fat/water ratio was significantly corre...Continue Reading

Citations

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