Fatty Liver as a Potential Surrogate for Waist Circumference in the Diagnosis of Metabolic Syndrome: A Population-Based Study among Chinese Adults

International Journal of Endocrinology
Boren JiangYingli Lu

Abstract

Increased waist circumference (WC) is an essential component of metabolic syndrome (MetS). Asians have been found to have more intra-abdominal adipose tissue than Caucasians, in spite of having smaller WC. The purpose of this study was to explore whether NAFLD could be used as a surrogate for MetS diagnosis in the normal WC population. A total of 9694 Chinese residents were selected from SPECT-China, a population-based survey of Chinese adults aged ≥ 18 years in East China. Insulin resistance was calculated by the homeostatic model assessment for insulin resistance (HOMA-IR). MetS z-score was used to evaluate the degree of total metabolic disorder. Logistic regression models were used to obtain the associations between different categories and metabolic syndrome (MetS) components. The prevalence of NAFLD was 27.6%, in which 35.2% were without abnormal WC. Subjects with only NAFLD had similarly severe insulin resistance and OR for clustering of MetS components compared with those with only abnormal WC. A considerable number of NAFLD cases, although had severe metabolic disorder, would not be detected by the current MetS definition. NAFLD could be used as a potential surrogate marker for the diagnosis of MetS in normal WC populat...Continue Reading

References

Apr 28, 2007·World Journal of Gastroenterology : WJG·Masahide HamaguchiToshikazu Yoshikawa
Jun 5, 2007·Clinics in Liver Disease·Phunchai Charatcharoenwitthaya, Keith D Lindor
Aug 13, 2008·Archives of Internal Medicine·Norbert StefanHans-Ulrich Häring
Aug 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Elisa FabbriniSamuel Klein
Mar 12, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kausik DasAbhijit Chowdhury
Mar 26, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Elizabeth K SpeliotesCaroline S Fox
Feb 25, 2011·Diabetology & Metabolic Syndrome·Fernanda Bu PulziJoão E Salles
Jun 10, 2011·Asia-Pacific Journal of Public Health·Tsui-Yen Chang, Jong-Dar Chen
Mar 20, 2013·Nature Reviews. Gastroenterology & Hepatology·Quentin M AnsteeChristopher P Day
Nov 30, 2013·Endocrine·Joseph M PappachanArjun Mukherjee
Sep 10, 2014·Best Practice & Research. Clinical Gastroenterology·Nicolas Lanthier, Isabelle A Leclercq
Mar 24, 2016·The Journal of Clinical Endocrinology and Metabolism·Ningjian WangYingli Lu
Apr 12, 2016·Clinics in Liver Disease·Kristina R Chacko, John Reinus

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Citations

Feb 25, 2020·European Journal of Gastroenterology & Hepatology·Jialiang ChenShukun Yao

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