PMID: 6987342Mar 1, 1980Paper

Fatty liver due to disproportionally added methionine to a low soybean diet and lipotropic action of phosphatides in rats

The Journal of Nutrition
K Noda, T Okita

Abstract

Young female rats of the Wistar strain were fed a 20% soybean diet (approximately 8% soybean protein) with or without the supply of 0.3% methionine. Methionine supply caused an accumulation of triglycerides in the liver. In vitro incorporation of acetate-1-14C into the liver lipid fraction and its incorporation ratios of triglyceride/phospholipid were higher in the livers from rats fed the methionine-supplemented diet (Met diet) than in those of animals fed the 20% soybean diet (basal diet). In vivo incorporation of 32P into the phospholipid fraction was lower in the livers of rats fed the Met diet than in those of rats fed the basal diet. Injection of phospholipid (lecithin) through a tail vein increased the plasma level of esterified fatty acids in rats fed the Met diet only and not in those fed the basal diet. Injection of an apolipoprotein fraction produced no effect on the plasma esterified fatty acid levels. The effect of phospholipids in increasing triglyceride transport was confirmed in liver perfusion experiments. These results indicate that supplying methionine to the low soybean protein diet induced disproportionation of synthesis and transport of triglycerides by the shortage of phospholipids.

Citations

May 23, 2006·Metabolism: Clinical and Experimental·William D ReesMorven Cruickshank

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.