Favorable effect of optimal lipid-lowering therapy on neointimal tissue characteristics after drug-eluting stent implantation: qualitative optical coherence tomographic analysis

Atherosclerosis
Ji-Yong JangMyeong-Ki Hong

Abstract

Serial follow-up optical coherence tomography (OCT) was used to evaluate the effect of optimal lipid-lowering therapy on qualitative changes in neointimal tissue characteristics after drug-eluting stent (DES) implantation. DES-treated patients (n = 218) who received statin therapy were examined with serial follow-up OCT. First and second follow-up OCT evaluations were performed approximately 6 and 18 months after the index procedure, respectively. Patients were divided into two groups, based on the level of low-density lipoprotein-cholesterol (LDL-C), which was measured at the second follow-up. The optimal lipid-lowering group (n = 121) had an LDL-C reduction of ≥50% or an LDL-C level ≤70 mg/dL, and the conventional group (n = 97). Neointimal characteristics were qualitatively categorized as homogeneous or non-homogeneous patterns using OCT. The non-homogeneous group included heterogeneous, layered, or neoatherosclerosis patterns. Qualitative changes in neointimal tissue characteristics between the first and second follow-up OCT examinations were assessed. Between the first and second follow-up OCT procedures, the neointimal cross-sectional area increased more substantially in the conventional group (0.4 mm(2) vs. 0.2 mm(2) in ...Continue Reading

References

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Citations

Jan 20, 2016·Current Treatment Options in Cardiovascular Medicine·Patrick M LooserDmitriy N Feldman
Sep 30, 2016·European Heart Journal Cardiovascular Imaging·Tomasz RolederZiad A Ali
Jul 7, 2018·BioMed Research International·Bugra Ozkanİsmail Türkay Özcan
Sep 11, 2018·Circulation Journal : Official Journal of the Japanese Circulation Society·Jung-Hee LeeYangsoo Jang
Jan 14, 2021·Cardiovascular Intervention and Therapeutics·Shoichi KuramitsuTakeshi Kimura
Jan 29, 2021·Circulation Journal : Official Journal of the Japanese Circulation Society·Atsushi KyodoYoshihiko Saito

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