Favorable Effects of Tacrolimus Monotherapy on Myasthenia Gravis Patients

Frontiers in Neurology
Zhirong FanYuwei Da

Abstract

Background and Purpose: Tacrolimus (TAC) has been proven to be a rapid-acting, steroid-sparing agent for myasthenia gravis (MG) therapy. However, evidence related to the effectiveness of TAC alone is rare. Therefore, this study was performed to investigate the effect of TAC monotherapy in MG patients. Methods: Forty-four MG patients who received TAC monotherapy were retrospectively analyzed. A mixed effect model was used to analyze improvements in MG-specific activities of daily living scale (MG-ADL), quantitative MG score (QMG) and MG-ADL subscores. Kaplan-Meier analysis was used to estimate the cumulative probability of minimal manifestations (MM) or better. Adverse events (AEs) were recorded for safety analyses. Results: Of the patients receiving TAC monotherapy, MG-ADL scores were remarkably improved at 3, 6 and 12 months compared with scores at baseline (mean difference and 95% CIs: -3.29 [-4.94, -1.64], -3.97 [-5.67, -2.27], and -4.67 [-6.48, -2.85], respectively). QMG scores significantly decreased at 6 and 12 months, with mean differences and 95% CIs of -4.67(-6.88, -2.45) and -5.77 (-7.55, -4.00), respectively. Estimated median period to achieve "MM or better" was 5.0 (95% CIs, 2.8, 7.2) months. Ocular MG (OMG) and gen...Continue Reading

References

Jul 1, 1979·Annals of Neurology·F E LeporeJ T Slevin
Jan 1, 1985·Advances in Clinical Chemistry·G D Calvert, M Abbey
Jun 1, 1984·Annals of Neurology·A S WitteN J Schatz
Jun 21, 1993·Annals of the New York Academy of Sciences·R S TindallK Hall
Mar 11, 1998·Harvard Review of Psychiatry·E S Brown, T Suppes
Aug 10, 2000·Neurology·E CiafaloniD B Sanders
Mar 27, 2001·Transplant International : Official Journal of the European Society for Organ Transplantation·W H GrotzP J Schollmeyer
Oct 23, 2003·Muscle & Nerve·Tetsuro KonishiUNKNOWN Japanese FK506 MG Study Group
Aug 25, 2004·Current Medical Research and Opinion·Naoki KawaguchiTakamichi Hattori
Sep 7, 2006·Kidney International·A ColliniM Carmellini
Oct 19, 2007·The Cochrane Database of Systematic Reviews·I K HartT Sharshar
Feb 17, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Maarten NaesensMinnie Sarwal
Oct 10, 2009·Muscle & Nerve·Yuriko NaganeKimiaki Utsugisawa
Jul 26, 2011·Journal of Neurology, Neurosurgery, and Psychiatry·Hiroaki YoshikawaMasaharu Takamori
Apr 4, 2013·European Neurology·Yohsuke YagiHidehiro Mizusawa
Aug 8, 2013·Pharmacogenetics and Genomics·Julia M BarbarinoRuss B Altman
Jul 30, 2014·Acta Neurologica Scandinavica·S HoffmannA Meisel
Jun 9, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M A SikmaJ Meulenbelt
Jul 1, 2016·Neurology·Donald B SandersPushpa Narayanaswami
Nov 23, 2016·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Xiaoyong TaoXusheng Huang
Dec 15, 2016·Physiology & Behavior·Preshanta NaickerJustin J Kavanagh
Jan 20, 2017·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·T KanaiS Kuwabara
Oct 23, 2017·Clinical Therapeutics·J Bradford RiceWinnie W Nelson
Jan 30, 2018·Annals of the New York Academy of Sciences·Hiroyuki MuraiMasakatsu Motomura
Jul 31, 2018·Current Neurology and Neuroscience Reports·Abdul Albilali, Esma Dilli
May 3, 2019·Nature Reviews. Disease Primers·Nils Erik GilhusJan J G M Verschuuren
Jun 30, 2019·Yonsei Medical Journal·Yool Hee KimSeung Min Kim

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.