Abstract
The combination of L(-)-2',3'-dideoxy-3'-thiacytidine (L(-)SddC, 3TC), L(-)-2',3'-dideoxy-5-fluorocytidine (L(-)FddC), or L(-)-2',3'-dideoxy-5-fluoro-3'-thiacytidine (L(-)(FTC) with 3'-azido-3'-deoxythymidine (AZT) synergistically inhibited replication of human immunodeficiency virus (HIV) in vitro. Similar synergistic activity was also obtained when these compounds were used in combination with 2',3'-didehyro-2',3'-dideoxythymidine (D4T). In terms of 2',3'- dideoxyinosime (ddI) and 2',3'-dideoxycytidine (ddC), only additive anti-HIV activity was observed. None of the beta-L(-) nucleoside analogues had additive toxicity in cell culture, and they could protect against the delayed mitochondrial toxicity associated with AZT, D4T, ddC, and ddI in drug-treated cells. Thus, combinations of beta-L(-) nucleoside analogues with any of the approved anti-HIV drugs could have a potentially beneficial outcome.
References
Nov 1, 1992·Antimicrobial Agents and Chemotherapy·R F SchinaziP A Furman
Jul 11, 1992·Antimicrobial Agents and Chemotherapy·J J EronM S Hirsch
Jan 1, 1992·Annals of Internal Medicine·T C MengD D Richman
Jan 1, 1992·Antimicrobial Agents and Chemotherapy·J A CoatesC R Penn
Feb 1, 1991·Antimicrobial Agents and Chemotherapy·R E DornsifeD R Averett
Sep 8, 1990·Lancet·C A BoucherB A Larder
Mar 1, 1990·Antimicrobial Agents and Chemotherapy·B A LarderD D Richman
Dec 1, 1993·Antiviral Research·E L WhiteW M Shannon
Oct 1, 1994·Antimicrobial Agents and Chemotherapy·A FarajJ P Sommadossi
Aug 4, 1995·Science·B A LarderP R Harrigan
Apr 1, 1993·Antimicrobial Agents and Chemotherapy·R F SchinaziJ W Mellors
May 1, 1993·Antimicrobial Agents and Chemotherapy·W B ParkerL L Bennett
Jan 20, 1994·Biochemical Pharmacology·T S LinY C Cheng
Jan 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·T ShirasakaH Mitsuya
Citations
Dec 10, 1999·Antiviral Research·F Zoulim
Oct 6, 2000·Drug Discovery Today·R F Rando, N Nguyen-Ba
Aug 27, 2005·Mitochondrion·Tamir DaganMariana Gerschenson
Jul 29, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J T LonerganW C Mathews
Dec 3, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael S Saag
Feb 18, 2010·AIDS·Jessica RadzioNicolas Sluis-Cremer
Apr 24, 2004·Antimicrobial Agents and Chemotherapy·Ginger E DutschmanYung-Chi Cheng
Apr 28, 2005·Antimicrobial Agents and Chemotherapy·Adrian S RayKaren S Anderson
Jul 29, 2005·Antimicrobial Agents and Chemotherapy·Takao NitandaMasanori Baba
Jun 13, 2001·Sexually Transmitted Infections·A J White
May 15, 2009·Retrovirology·Joy Y FengMichael D Miller
Apr 24, 2009·AIDS Research and Therapy·Elijah PaintsilYung-Chi Cheng
Aug 30, 2008·Antiviral Chemistry & Chemotherapy·Erik De Clercq, Hugh J Field
Jun 7, 2003·Antiviral Chemistry & Chemotherapy·Susan Erickson-ViitanenRaymond F Schinazi
Aug 6, 2014·Antimicrobial Agents and Chemotherapy·Rima KulkarniKirsten L White
Dec 6, 2002·Drugs·Susan M Cheer, Karen L Goa
Apr 25, 2001·The Journal of Biological Chemistry·S E Lim, W C Copeland
Jul 14, 1998·Antimicrobial Agents and Chemotherapy·G E DutschmanY C Cheng
Apr 2, 1999·Antimicrobial Agents and Chemotherapy·L T MartinJ P Sommadossi
Oct 23, 1997·Biochemical Pharmacology·S KewnD J Back
Jun 6, 2000·Advanced Drug Delivery Reviews·X TanF D Boudinot