Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes

Proceedings of the National Academy of Sciences of the United States of America
Barbara LudwigStefan R Bornstein

Abstract

Transplantation of pancreatic islets for treating type 1 diabetes is restricted to patients with critical metabolic lability resulting from the need for immunosuppression and the shortage of donor organs. To overcome these barriers, we developed a strategy to macroencapsulate islets from different sources that allow their survival and function without immunosuppression. Here we report successful and safe transplantation of porcine islets with a bioartificial pancreas device in diabetic primates without any immune suppression. This strategy should lead to pioneering clinical trials with xenotransplantation for treatment of diabetes and, thereby, represents a previously unidentified approach to efficient cell replacement for a broad spectrum of endocrine disorders and other organ dysfunctions.

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Citations

May 24, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Alexandra M SminkPaul de Vos
Dec 7, 2018·Nature Reviews. Endocrinology·Mostafa BakhtiHeiko Lickert
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Apr 5, 2020·Journal of Diabetes·Shinichi Matsumoto, Masayuki Shimoda
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Sep 20, 2018·Current Diabetes Reports·Elisabeth KemterEckhard Wolf
Jun 10, 2020·Expert Opinion on Drug Delivery·Lukin IzeiaGorka Orive
Jan 8, 2021·International Journal of Immunogenetics·Marco Carvalho-OliveiraConstanca Figueiredo
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Mar 26, 2021·Diabetologia·Felicia GerstSusanne Ullrich
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Oct 8, 2021·Nature Communications·Long-Hai WangMinglin Ma
Oct 8, 2021·Xenotransplantation·Wayne J HawthorneChristopher Burlak

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