Favourable prognostic factors in a large UK experience of adenocarcinoma of the head of the pancreas and periampullary region

Digestive Surgery
N P JarufeS R Bramhall

Abstract

To present the surgical experience in a regional unit, analysing the post-operative outcome, and determining risk factors for survival after pancreaticoduodenectomy for periampullary and pancreatic head carcinoma. Data were collected on 251 patients with pancreatic head adenocarcinoma (133), ampullary carcinomas (88) and distal common bile duct (30), between 1987 and 2002. Survival was calculated using the Kaplan-Meier method. Clinical, surgical and histopathological records were examined by univariate and multivariate analysis to identify the independent prognostic predictors of survival. Median actuarial survival for carcinoma of the pancreatic head, ampulla and distal bile duct were 13.4, 35.5 and 16 months, respectively; p < 0.0001. On univariate analysis for the whole series, the age < or =60, tumour of the head of the pancreas, lymph node positive, resection margin R1, poorly differentiated tumours, and portal vein invasion significantly decreased survival. On multivariate analysis, poor tumour differentiation, surgical margin, lymph node metastases, and age independently influence survival. Mortality and morbidity were 4.8 and 29.9%, respectively. Pancreaticoduodenectomy for pancreatic and periampullary tumours is the on...Continue Reading

References

Sep 1, 1990·The British Journal of Surgery·P A GraceW P Longmire
Jun 15, 1994·International Journal of Cancer. Journal International Du Cancer·E FernandezF Levi
Aug 3, 1996·Lancet·P SelbyR Haward
Mar 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F R SpitzD B Evans
Jun 24, 1998·Annals of Surgery·C J YeoH A Pitt
Sep 5, 1998·Cancer Treatment Reviews·C KollmannsbergerU Fink
Mar 29, 2000·CA: a Cancer Journal for Clinicians·R T GreenleeP A Wingo
Apr 18, 2001·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·T A SohnK D Lillemoe
Aug 25, 2001·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·R C van GeenenD J Gouma
Apr 12, 2002·The New England Journal of Medicine·John D BirkmeyerDavid E Wennberg
Jan 30, 2003·The British Journal of Surgery·M O BachmannI M Harvey
Apr 19, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J P NeoptolemosM W Büchler
Jul 16, 2003·Archives of Surgery·Emily V A FinlaysonJohn D Birkmeyer
Mar 19, 2004·The New England Journal of Medicine·John P NeoptolemosUNKNOWN European Study Group for Pancreatic Cancer

❮ Previous
Next ❯

Citations

Apr 27, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Thomas ZachariasPhilippe Bachellier
Sep 4, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Carlos ChanLuis Uscanga
Jan 9, 2013·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Nigel B JamiesonC Ross Carter
Sep 16, 2005·Current Treatment Options in Gastroenterology·Gauri R VaradhacharyRobert A Wolff
May 4, 2012·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Kyubo KimSung W Ha
Mar 21, 2008·Annals of Surgical Oncology·Irene EspositoMarkus W Büchler
Jan 22, 2014·International Surgery·Alireza Hamidian JahromiHosein Shokouh-Amiri
Mar 8, 2014·World Journal of Gastroenterology : WJG·Jin HeTimothy M Pawlik
Mar 26, 2016·Surgical Oncology Clinics of North America·Beth A HelminkAlexander A Parikh
Apr 3, 2016·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·James R ButlerNicholas J Zyromski
Feb 7, 2012·Annals of Vascular Surgery·Ryan S TurleyRebekah R White
Jul 12, 2011·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A LazaryanR Kim
Mar 8, 2011·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Suzanne M JeurninkUNKNOWN Dutch SUSTENT Study Group
Mar 12, 2013·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Jin HeChristopher L Wolfgang
Oct 18, 2008·Journal of the American College of Surgeons·Karl Y BilimoriaDavid J Bentrem
Mar 18, 2008·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·P O BerberatM W Büchler
Apr 3, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·G GarceaD P Berry
Apr 21, 2012·The British Journal of Surgery·C S Verbeke, I P Gladhaug
Sep 16, 2011·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Arne WestgaardIvar P Gladhaug
Nov 26, 2015·Journal of Surgical Oncology·Cecilia G Ethun, David A Kooby
May 10, 2016·Journal of Surgical Oncology·Matthew P DoepkerPamela J Hodul
Jun 29, 2006·The British Journal of Surgery·C S VerbekeA Anthoney
Oct 28, 2019·Surgery Today·Suguru YamadaYasuhiro Kodera
Nov 1, 2017·World Journal of Gastrointestinal Oncology·Manju D ChandrasegaramNeil D Merrett
Nov 26, 2020·Annals of Hepato-biliary-pancreatic Surgery·Sundeep Singh SalujaVaibhav Kumar Varshney

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.