PMID: 6108777Dec 1, 1980Paper

Fazadinium and pancuronium: a pharmacodynamic study

British Journal of Anaesthesia
C J HullA Sibbald

Abstract

The neuromuscular blocking characteristics of fazadinium and pancuronium were compared using a general pharmacodynamic model. Since it characterizes the overall relationship between dose and effect, the model can be used to determine precisely equipotent doses, compare time-effect curves, and reconcile the apparently inconsistent clinical and pharmacokinetic characteristics of the two drugs. Fazadinium was shown to have a shorter duration than pancuronium, and appeared to exhibit less variation between subjects. The potency ratio varied between 3.4 : 1 and 7.2 : 1, depending upon the definition chosen. A general solution for the three-compartment open mammillary model, following any set of initial conditions if presented as an appendix. These equations allow explicit computation of any pattern of drug incrementation into any compartment of the model.

Citations

Jan 1, 1983·European Journal of Clinical Pharmacology·A A d'HollanderJ M Desmonts
Oct 1, 1982·European Journal of Clinical Pharmacology·P DuvaldestinA D'Hollander
Sep 1, 1986·Canadian Anaesthetists' Society Journal·F DonatiD R Bevan
Aug 1, 1995·Clinical Pharmacology and Therapeutics·L B Sheiner, D Verotta
Jun 1, 1997·Anaesthesia and Intensive Care·T A TordaN R Warwick
Feb 1, 1987·Anaesthesia and Intensive Care·G H Beemer
Jan 1, 1992·Journal of Anesthesia·T Nomura

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.